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ProteomicsDisordered region encodes α-crystallin chaperone activity toward lens client γD-crystallin
Small heat-shock proteins (sHSPs) are a widely expressed family of ATP-independent molecular chaperones that are among the first responders to cellular stress. Mechanisms by which sHSPs delay aggregation of client proteins remain undefined. sHSPs have high intrinsic disorder content of up to ~60% an...
ORGANISM(S): Escherichia coli 
2023-01-31 | PXD035668 | Pride
Hspb5 Small heat shock proteins Crosslinking Bpa 
ProteomicsActivation mechanism of Small Heat Shock Protein HSPB5 revealed by disease-associated mutants.
Found from bacteria to humans, small heat shock proteins (sHSPs) are the least understood protein chaperones. HSPB5 (or αB-crystallin) is among the most widely expressed of the 10 human sHSPs, including in muscle, brain, and eye lens where it is constitutively present at high levels. A high content ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-04-22 | PXD055848 | Pride
Small heat shock proteins Crosslinking mass spectrometry 
UnknownCell-free synthesis of functionally active HSPB5.
Not available
S-EPMC7058722 | biostudies-literature
UnknownTrends in HSPB5 research: a 36-year bibliometric analysis.
Not available
S-EPMC8492881 | biostudies-literature
UnknownHeat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis.
Not available
S-EPMC6194336 | biostudies-literature
UnknownDisorder with consequence: Phosphorylation sites in HSPB5 yield distinct structural outcomes.
Not available
S-EPMC12636291 | biostudies-literature
UnknownChaperone-Like Activity of HSPB5: The Effects of Quaternary Structure Dynamics and Crowding.
Not available
S-EPMC7404038 | biostudies-literature
UnknownActivation mechanism of small heat shock protein HSPB5 revealed by disease-associated mutants.
Not available
S-EPMC12107100 | biostudies-literature
UnknownHSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling.
Not available
S-EPMC9960643 | biostudies-literature
UnknownSmall heat shock protein HSPB5 uses disorder to bind zinc with high affinity.
Not available
S-EPMC12632755 | biostudies-literature
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