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MetabolomicsIntegrated multi-omics analysis reveals insulin-induced metabolic adaptation of Hu sheep skeletal muscle satellite cells: inhibiting proliferation while promoting myogenesis

Background Skeletal muscle satellite cells (SMSCs) possess bidirectional differentiation potential and are potential targets for improving meat quality in animal production. However, SMSCs do not spontaneously undergo adipogenesis, and insulin is a classic...

2026-10-27 | MTBLS15376 | MetaboLights
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
TranscriptomicsKc167 ORC Localization in hydroxyurea (HU)
Determination of the genome-wide distribution of ORC by chromatin immunoprecipitation in the Drosophila Kc167 cell line at the beginning of S phase. Kc167 cells were arrested at the G1/S transition with hydroxyurea (HU). Goal was to test whether the ORC binding distribution remained the same betwe...
ORGANISM(S): Drosophila melanogaster 
2014-12-05 | E-GEOD-63914 | biostudies-arrayexpress
TranscriptomicsKc167 Mcm2-7 Localization in HU
Determination of the genome-wide distribution of the Mcm2-7 helicase by chromatin immunoprecipitation in the Drosophila Kc167 cell line at the beginning of S phase. Kc167 cells were arrested at the G1/S transition with hydroxyurea (HU). Goal was to evaluate changes in the genome-wide Mcm2-7 distri...
ORGANISM(S): Drosophila melanogaster 
2014-11-27 | E-GEOD-63680 | biostudies-arrayexpress
UnknownTetracycline Removal by Activating Persulfate with Diatomite Loading of Fe and Ce.
Not available
S-EPMC7728345 | biostudies-literature
TranscriptomicsAccumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication
Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA damaging agents such as methyl meth...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-14761 | biostudies-arrayexpress
TranscriptomicsTemporally defined neocortical translation and polysome assembly is determined by the RNA-binding protein, Hu antigen R
Precise spatiotemporal control of mRNA translation machinery is essential to proper development of highly complex systems like the neocortex. Here, we show that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical translation machinery in a deve...
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-50809 | biostudies-arrayexpress
UnknownTherapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection.
Not available
S-EPMC6067903 | biostudies-literature
UnknownGag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques.
Not available
S-EPMC6183272 | biostudies-literature
UnknownCu-Ce Dual-Atom Sites Embedded in Zeolites Boost Resistance to Impurity Interference for Environmental Catalysis.
Not available
S-EPMC12668302 | biostudies-literature
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