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MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
TranscriptomicsGene expression from SCID-hu mice treated with saline (control) or intermittent PTH
The data present global gene expression profile of whole human bones, implanted in SCID mice (SCID-hu model), then engrafted with the myeloma cell line, Hg, and treated with saline or PTH for 4 weeks. SCID-hu mice were prepared by subcutaneous implantation of human bone in SCID mice. The human myelo...
ORGANISM(S): Homo sapiens 
2013-09-10 | E-GEOD-24068 | biostudies-arrayexpress
TranscriptomicsExpression changes in Tetrahymena thermophila TRX1 and EZL2 gene knockouts and after hydroxyurea (HU) treatment
12 genome-wide microarrays to investigate the Tetrahymena thermophila gene expression changes in TRX1 and EZL2 gene knockout and hydroxyurea (HU) treatment conditions. For the TRR1 knockout (KO) condition, wild type (WT427) cells and TRX1 KO cells were cultured using 1XSPP, 30 degrees, 100 rpm shaki...
ORGANISM(S): Tetrahymena thermophila 
2013-09-04 | E-GEOD-44990 | biostudies-arrayexpress
UnknownD-DI/PLT can be a prognostic indicator for sepsis.
Not available
S-EPMC10487589 | biostudies-literature
TranscriptomicsKc167 ORC Localization in hydroxyurea (HU)
Determination of the genome-wide distribution of ORC by chromatin immunoprecipitation in the Drosophila Kc167 cell line at the beginning of S phase. Kc167 cells were arrested at the G1/S transition with hydroxyurea (HU). Goal was to test whether the ORC binding distribution remained the same betwe...
ORGANISM(S): Drosophila melanogaster 
2014-12-05 | E-GEOD-63914 | biostudies-arrayexpress
TranscriptomicsKc167 Mcm2-7 Localization in HU
Determination of the genome-wide distribution of the Mcm2-7 helicase by chromatin immunoprecipitation in the Drosophila Kc167 cell line at the beginning of S phase. Kc167 cells were arrested at the G1/S transition with hydroxyurea (HU). Goal was to evaluate changes in the genome-wide Mcm2-7 distri...
ORGANISM(S): Drosophila melanogaster 
2014-11-27 | E-GEOD-63680 | biostudies-arrayexpress
TranscriptomicsS phase and HU profiles in wild-type and mutant cells
Total S phase was measured for wild-type cells undergoing meiS and mitS. Early replication origins were mapped in mitS in wild-type cells, and in meiS for wild-type, sml1 delete, rec8 delete and spo11 delete cells. Comparative genome hybridization was used to measure the kinetics and final extent of...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-18 | E-GEOD-35662 | biostudies-arrayexpress
TranscriptomicsA Highly Sensitive and Unbiased Approach for Elucidating Antibody Repertoires
Developing B lymphocytes undergo V(D)J recombination to assemble germline V, D, and J gene segments into exons that encode the antigen-binding variable region of immunoglobulin (Ig) heavy (H) and light (L) chains. IgH and IgL chains associate to form the B cell receptor (BCR), which upon antigen bi...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82126 | biostudies-arrayexpress
UnknownCyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense.
Not available
S-EPMC6101608 | biostudies-literature
Unknownc-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin
Not available
S-SCDT-10_1038-S44319-025-00377-W | biostudies-other
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