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MetabolomicsTranscriptome and metabolome changes in Chinese cedar during cold acclimation reveal the roles of flavonoids in needle discoloration and cold resistance

Cryptomeria fortunei growth and development are usually affected by low temperatures. Despite the evergreen nature of this species, most needles turn yellowish-brown in cold winters. The underlying discoloration mechanisms that cause this phenomenon in response to cold acclimation remain...

2022-08-12 | MTBLS3184 | MetaboLights
MetabolomicsIntegrated Four Comparative-Omics Reveals the Mechanism of the Terpenoid Biosynthesis in Two Different Overwintering Cryptomeria fortunei Phenotypes
Chinese cedar (Cryptomeria fortunei) is a tree species with important ornamental, medicinal, and economic value. Terpenoids extracted from the essential oil of C. fortunei needles have been considered valuable ingredients in the pharmaceutical and cosmetic industries. However, the poss...
2022-08-12 | MTBLS3183 | MetaboLights
ProteomicsMS-based analysis of the interacting proteins of human topoisomerases (TOP1, TOP2A, TOP2B)
In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several o...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056277 | Pride
Mass spectrometry Protein interaction Human Proteomics Topoisomerases 
ProteomicsMS-based analysis of the interacting proteins of human topoisomerases (TOP3A, TOP3B)
In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several o...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056278 | Pride
Mass spectrometry Protein interaction Human Proteomics Topoisomerases 
ProteomicsPhosphoproteomics analysis of CHK1 inhibitor treatment
Inhibitors of checkpoint kinase 1 (CHK1),a central component of DNA damage and cell cycle checkpoint response, represent a promising new cancer therapy, but the global cellular functionsthey regulate through phosphorylationare poorly understood. To elucidate the CHK1-regulated phosphorylation networ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD015125 | Pride
Chk1 inhibitor Silac Phosphoprotomics 
TranscriptomicsInfluence of ATM-mediated DNA damage response on genomic variation in human induced pluripotent stem cells (NimbleGen CNV)
Genome instability is a potential limitation to the research and therapeutic application of induced pluripotent stem cells (iPSCs). Observed genomic variations reflect the combined activities of DNA damage, cellular DNA damage response (DDR), and selection pressure in culture. To understand the cont...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-78717 | biostudies-arrayexpress
TranscriptomicsInfluence of ATM-mediated DNA damage response on genomic variation in human induced pluripotent stem cells (Affymetrix expression)
Genome instability is a potential limitation to the research and therapeutic application of induced pluripotent stem cells (iPSCs). Observed genomic variations reflect the combined activities of DNA damage, cellular DNA damage response (DDR), and selection pressure in culture. To understand the cont...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-78716 | biostudies-arrayexpress
TranscriptomicsInfluence of ATM-mediated DNA damage response on genomic variation in human induced pluripotent stem cells (Affymetrix CNV)
Genome instability is a potential limitation to the research and therapeutic application of induced pluripotent stem cells (iPSCs). Observed genomic variations reflect the combined activities of DNA damage, cellular DNA damage response (DDR), and selection pressure in culture. To understand the cont...
ORGANISM(S): Homo sapiens 
2016-03-29 | E-GEOD-78715 | biostudies-arrayexpress
MetabolomicsTranscriptome and Metabolome Analyses Reveal Differences in Terpenoid and Flavonoid Biosynthesis in Cryptomeria fortunei Needles Across Different Seasons

Cryptomeria fortunei (Chinese cedar) has outstanding medicinal value due to its abundant flavonoid and terpenoid contents. The metabolite contents of C. fortunei needles differ across different seasons. However, the biosynthetic mechanism of these differentially synthesized meta...

2022-08-12 | MTBLS4099 | MetaboLights
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-proteomic sequencing
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062097 |
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