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TranscriptomicsExpression data from lack of DNA topoisomerase I, DNA topoisomerase II and complete lack of both topoisomerases
Here we dissect the transcriptional response in S. cerevisiae cells lacking DNA topoisomerases. We use microarray technology coupled with a functional genomics approach and demonstrate intimate connections between topoisomerase dependency, promoter chromatin architecture and gene transcription. Our ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-07-31 | E-GEOD-22809 | biostudies-arrayexpress
ProteomicsMS-based analysis of the interacting proteins of human topoisomerases (TOP3A, TOP3B)
In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several o...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056278 | Pride
Mass spectrometry Protein interaction Human Proteomics Topoisomerases 
ProteomicsMS-based analysis of the interacting proteins of human topoisomerases (TOP1, TOP2A, TOP2B)
In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several o...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056277 | Pride
Mass spectrometry Protein interaction Human Proteomics Topoisomerases 
TranscriptomicsCo-ordinate inhibition of autism candidate genes by topoisomerase inhibitors [Seq]
Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomer...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43526 | biostudies-arrayexpress
GenomicsDifferential Roles of Type I Topoisomerases in Regulating HPV Pathogenesis
Differential Roles of Type I Topoisomerases in Regulating HPV Pathogenesis
PRJNA1374109 | ENA
UnknownTopoisomerases as anticancer targets.
Not available
S-EPMC6110615 | biostudies-literature
TranscriptomicsCo-ordinate inhibiton of autism candidate genes by topoisomerase inhibitors [array]
Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomer...
ORGANISM(S): Mus musculus 
2013-08-30 | E-GEOD-43899 | biostudies-arrayexpress
GenomicsFork Pausing Complex Engages Topoisomerases at the Replisome
Fork Pausing Complex Engages Topoisomerases at the Replisome
PRJNA588062 | ENA
GenomicsBacterial type II topoisomerases cleave DNA in a species-specific manner
Bacterial type II topoisomerases cleave DNA in a species-specific manner
PRJNA1297677 | ENA
UnknownDNA-Topology Simplification by Topoisomerases.
Not available
S-EPMC8199745 | biostudies-literature
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