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TranscriptomicsTemporally defined neocortical translation and polysome assembly is determined by the RNA-binding protein, Hu antigen R
Precise spatiotemporal control of mRNA translation machinery is essential to proper development of highly complex systems like the neocortex. Here, we show that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical translation machinery in a deve...
ORGANISM(S): Mus musculus 
2014-08-25 | E-GEOD-50809 | biostudies-arrayexpress
TranscriptomicsIdentification of transformation-related pathways in a breast epithelial cell model using a ribonomics approach.
Employing MCT-1 oncogene mediated transformation of immortalized breast epithelial MCF10A cells; we characterized the largely reciprocal association of these two RBPs with target mRNAs and their influence on protein expression vis-à-vis cellular transformation. Using a ribonomics approach, we ident...
ORGANISM(S): Homo sapiens 
2008-07-29 | E-GEOD-12215 | biostudies-arrayexpress
ProteomicsProteomic and Glycoproteomic Analyses of Fucosylated Glycoproteins in Head and Neck Cancer Cell Lines
Peptide and glycopeptide level LC-MS/MS analysis of whole cell lysate and Aleuria aurantia Lectin (AAL)-enriched glycoproteins.
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD029420 | Pride
Human Oral cancer Fucosylation Lewis y Head and neck cancer Fut2 Hnscc 
Genomicsena-DATASET-HU-17-07-2017-20:03:05:530-176 - samples
This dataset includes deep coverage (>60x) whole exomes of 15 human embryonic stem cell lines. Genomic DNA was purified and fragmented using the Illumina Nextera system for library preparation and sequenced using 150bp paired-end reads. Sequencing reads were aligned to the hg19 reference genome usin...
EGAD00001003446 | EGA
TranscriptomicsTranscription profiling of aging human muscle
We analyzed expression of 81 normal muscle samples from humans of varying ages, and have identified a molecular profile for aging consisting of 250 age-regulated genes. This molecular profile correlates not only with chronological age but also with a measure of physiological age. We compared the tra...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5086 | biostudies-arrayexpress
TranscriptomicsATM regulates a DNA damage response post-transcriptional RNA operon in lymphocytes
Maintenance of genomic stability depends on the DNA damage response (DDR), a biological barrier in early stages of cancer development. Failure of this response results in genomic instability and high predisposition toward lymphoma, as seen in patients with ataxia-telangiectasia mutated (ATM) dysfunc...
ORGANISM(S): Homo sapiens 
2011-01-05 | E-GEOD-25848 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal lung from 18 multi-organ donors to analyse variance of gene expression in lung
Peripheral sections of upper and lower lung from 18 human multi-organ donors without evidence of lung disease.
ORGANISM(S): Homo sapiens 
2007-10-02 | E-GEOD-1643 | biostudies-arrayexpress
TranscriptomicsSIRT1 but not its increased expression is essential for lifespan extension in caloric restricted mice.
The SIRT1 deacetylase is one of the best-studied potential mediators of some of the anti-aging effects of calorie restriction (CR); but its role in CR-dependent lifespan extension has not been demonstrated. We previously found that mice lacking both copies of SIRT1 displayed a shorter median lifespa...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-46895 | biostudies-arrayexpress
TranscriptomicsIntegrative AUF1 PAR-CLIP analysis uncovers AUF1 roles in translation and genome integrity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-52977 | biostudies-arrayexpress
TranscriptomicsIdentification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells
Retinal pigment epithelium (RPE) cells can be obtained through in vitro differentiation of both embryonic stem cell (ESC) and induced pluripotent stem cells (iPSC) for cell replacement therapy. We have previously identified 87 signature genes relevant to RPE cell differentiation and function through...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-37686 | biostudies-arrayexpress
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