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Proteomicsproteomics analysis haustorium development of Taxillus chinensis
Loranthus (Taxillus chinensis) is an important medicinal and parasitic plant that attacks other plants for living. To reveal the mechanisms of haustorium development, we employed an iTRAQ proteomics-based approach to identify differentially abundant proteins (DAPs) of fresh seeds (CK), baby (FB), an...
ORGANISM(S): Taxillus chinensis 
2022-10-14 | PXD029830 | Pride
Taxillus chinensis itraq haustorium 
TranscriptomicsGenomically amplified Akt3 activates DNA repair pathway and promotes glioma progression
Akt is a robust oncogene that plays key roles in the development and progression of many cancers, including glioma. We evaluated the differential propensities of the Akt isoforms toward progression in the well-characterized RCAs/Ntv-a mouse model of PDGFB-driven low grade glioma. A constitutively ac...
ORGANISM(S): Mus musculus 
2015-02-24 | E-GEOD-66177 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of glioblastoma cell lines transfected with FGFR3-TACC3
Gene expression profiling of SNB19 and U251 glioblastoma cell lines transfected with the FGFR3-TACC3 fusion, FGFR3 wildtype and TACC3 wildtype constructs. SNB19 and U251 cells were transfected with different clones of the FGFR3-TACC3 fusion and with wildtype FGFR3 and TACC3 constructs. Total RNA was...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42401 | biostudies-arrayexpress
TranscriptomicsIGFBP2 driven glioma progression is prevented by blocking a clinically significant network of integrin, ILK, and NK-kB
Insulin-like growth factor-binding protein 2 (IGFBP2) is increasingly recognized as a glioma oncogene, emerging as a target for therapeutic intervention. In this study, we used an integrative approach to characterizing the IGFBP2 network, combining transcriptional profiling of human glioma with vali...
ORGANISM(S): Homo sapiens 
2012-02-02 | E-GEOD-35467 | biostudies-arrayexpress
ProteomicsCharacterization, Antioxidant Effects of Lycium ruthenicum Murr. Polysaccharides and its Protective Effects Against Oxaliplatin-Induced Peripheral Neurotoxicity by Inhibiting the RAS-RAF-MEK-ERK Signaling Pathway
Oxaliplatin is a frequently used chemotherapeutic agent; however, oxaliplatin-induced peripheral neuropathy (OIPN) is a prevalent adverse effect for which no effective treatment currently exists. Lycium ruthenicum Murr. (LR), a traditional Chinese medicinal herb also consumed as food, is rich in pol...
ORGANISM(S): Rattus Norvegicus 
2025-11-26 | PXD071288 |
TranscriptomicsInsulin-like growth factor-binding protein 2 Induces Epithelial-mesenchymal Transition via Activation of NF-M-NM-:B Pathway in Pancreatic Ductal Adenocarcinoma
IGFBP2 has been shown to act as an oncogene augmenting tumor progression in a number of malignancies. We sought to investigate role of IGFBP2 and its related pathways in PDAC. Gene expression profiling were used to reveal the key signaling pathways. Microarray experiments in IGFBP2-overexpressing ...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-64611 | biostudies-arrayexpress
TranscriptomicsThe tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42402 | biostudies-arrayexpress
TranscriptomicsHigh resolution aCGH of the FGFR3-TACC3 locus in glioblastoma patients
Targeted high resolution array comparative genomic hybridization of the 4p16.3 locus in seven glioblastoma patients A custom Agilent CGH microarray based on the 105A backbone was designed with high probe coverage for 4p16.3. Tumor tissue from four FGFR3-TACC3 positive patients and three negative pat...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42400 | biostudies-arrayexpress
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