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TranscriptomicsGene expression from SCID-hu mice treated with saline (control) or intermittent PTH
The data present global gene expression profile of whole human bones, implanted in SCID mice (SCID-hu model), then engrafted with the myeloma cell line, Hg, and treated with saline or PTH for 4 weeks. SCID-hu mice were prepared by subcutaneous implantation of human bone in SCID mice. The human myelo...
ORGANISM(S): Homo sapiens 
2013-09-10 | E-GEOD-24068 | biostudies-arrayexpress
GenomicsThe androgen receptor induces a distinct transcriptional program in castration resistant prostate cancer in man
The androgen receptor (AR) is the major transcriptional driver of prostate cell growth in man. For the first time, we define AR targets in prostate cancer (PC) tissue representing progression from treatment-naive to castrate-resistant disease (CRPC). We employed chromatin immunoprecipitation with hi...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-28219 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of human primary fibroblasts treated with 250µM HU versus untreated primary fibroblats
We analyzed the transcription response of human primary fibroblasts exposed (3 days) to a non blocking dose of HU (250µM). This dose of HU generates a replication stress, but the canonical DDR is not fully activated and the cells still proliferate and synthetize DNA; however, cells respond to such l...
ORGANISM(S): Homo sapiens 
2019-12-20 | E-MTAB-8605 | biostudies-arrayexpress
UnknownRole of malectin in Glc(2)Man(9)GlcNAc(2)-dependent quality control of α1-antitrypsin.
Not available
S-EPMC3183012 | biostudies-literature
TranscriptomicsTranscription profiling of human monocyte derived macrophages reveals induction of dendritic cell-like phenotype in macrophages during foam cell formation
Foam cell formation from monocyte-derived macrophages is a hallmark of atheroscle-rotic lesions. Aspects of this process can be recapitulated in vitro by exposing MCSF-induced or platelet factor4 (CXCL4)-induced macrophages to oxidized (ox) or minimally modified (mm) low density lipoprotein (LDL). W...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7138 | biostudies-arrayexpress
ProteomicsA Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells
In a previous study, we described the biochemical properties of a newly synthesized group of imidazopyrazole compounds. In this paper, to improve our knowledge on the pharmacological properties of these chemical compounds, we carry out a differential proteomic analysis on a hu-man melanoma cell line...
ORGANISM(S): Homo sapiens (Human) 
2024-06-21 | PXD049299 | Pride
Imidazopyrazole  cell growth inhibition  differential proteomic analysis  melanoma 
TranscriptomicsTranscriptional profiling of growth perturbations of the human malaria parasite Plasmodium falciparum
The microarray experiments were carried out using a long oligonucleotide DNA microarray that represent all 5363 P. falciparum genes with one oligonucleotide per 1.9kb of coding sequence on average (Hu et al. 2007). Total 247 microarray experiments were carried out including 29-drug treatment time co...
ORGANISM(S): Plasmodium falciparum 
2010-05-18 | E-GEOD-19468 | biostudies-arrayexpress
TranscriptomicsRsk2 controls synovial fibroblast hyperplasia and the course of arthritis.
To understand differences in the pathogenesis of synovial hyperplasia during TNF-induced arthritis, we compared the global gene expression of hTNFtg and hTNFtg;Rsk2-/y primary synovial fibroblasts. Murine fibroblast-like synoviocytes (FLS) were isolated from the hind paws of hTNFtg and hTNFtg;Rsk2-/...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-52992 | biostudies-arrayexpress
TranscriptomicsNf1 deletion and recurrent copy number alterations in mammary tumorigenesis
Breast cancer is the most prevalent cancer in women, and most cases are believed to have a sporadic, rather than heritable basis. Therefore, a major challenge in cancer research is to determine the underlying genomic alterations leading to carcinogenesis and malignancy, and then use this informati...
ORGANISM(S): Mus musculus 
2012-08-21 | E-GEOD-36240 | biostudies-arrayexpress
TranscriptomicsExpression data for T47D cells treated with 2mM hydroxyurea
RAD51B, a paralog of RAD51, have been associated with breast cancer risk in genome-wide association studies. The underlying biological mechanism through which germline genetic variation in RAD51B confers susceptibility to breast cancer is not well understood. Here we investigate the molecular functi...
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-56940 | biostudies-arrayexpress
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