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MetabolomicsRegulation impact of Duolang sheep-sourced Ligilactobacillus salivarius on rumen microbiome homeostasis and host metabolism in Hu sheep

Background: Hu sheep, renowned for their prolificacy and economic value, have been introduced to Xinjiang for intensive farming operations. However, their suboptimal adaptation to local harsh environments limits growth efficiency and health management. In contrast, Duolang sheep, an indigenous Xi...

2025-08-02 | MTBLS12659 | MetaboLights
MetabolomicsMetabolome of Streptomyces sp. HU2014

HU2014 was inoculated into an optimized medium containing dextrin (39.59 g/L), yeast extract (8.52 g/L), and KNO3 (2.49 g/L), with the initial pH adjusted to 7.0–7.3, and fermented at 25°C and 120 rpm for 15 days. Fermentation supernatants were collected at four time points: day 0 (C0/control), d...

2026-04-22 | MTBLS14352 | MetaboLights
MetabolomicsFermented cotton stalks preserve colonic epithelial integrity in Hu sheep by modulating the microbiota–metabolite–NF-kB/MLCK axis

This study compared three cotton-stalk processing strategies—grinding (FS), steam explosion (PH), and microbial fermentation (FJ)—and evaluated whether the barrier-preserving phenotype observed with fermented cotton stalks is associated with coordinated changes in the microbiota–metabolite milieu...

2026-03-18 | MTBLS14078 | MetaboLights
TranscriptomicsS phase and HU profiles in wild-type and mutant cells
Total S phase was measured for wild-type cells undergoing meiS and mitS. Early replication origins were mapped in mitS in wild-type cells, and in meiS for wild-type, sml1 delete, rec8 delete and spo11 delete cells. Comparative genome hybridization was used to measure the kinetics and final extent of...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-18 | E-GEOD-35662 | biostudies-arrayexpress
MetabolomicsIntegrated multi-omics analysis reveals insulin-induced metabolic adaptation of Hu sheep skeletal muscle satellite cells: inhibiting proliferation while promoting myogenesis

Background Skeletal muscle satellite cells (SMSCs) possess bidirectional differentiation potential and are potential targets for improving meat quality in animal production. However, SMSCs do not spontaneously undergo adipogenesis, and insulin is a classic...

2026-10-27 | MTBLS15376 | MetaboLights
TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
TranscriptomicsGenome-wide Profiling of DNA Replication Timing in pombe.
DNA replication is initiated at multiple sites or origins enriched with AT-rich sequences at various times during the S-phase. While current studies of genome-wide DNA replication profiles have focused on the timing of replication and the location of origins, the efficiency of replication/firing at...
ORGANISM(S): Schizosaccharomyces pombe 
2007-08-14 | E-GEOD-6977 | biostudies-arrayexpress
GenomicsE2F7 represses a transcriptional network of oscillating cell cycle genes to control S-phase progression.
E2F transcription factors are known to be important for timely activation of G1/S and G2/M genes required for cell cycle progression, but transcriptional mechanisms for deactivation of cell cycle regulated genes are unknown. Here, we show that E2F7 is highly expressed during mid to late S-phase, occ...
ORGANISM(S): Homo sapiens 
2012-01-04 | E-GEOD-32673 | biostudies-arrayexpress
ProteomicsS-nitrosoproteome of pancreatic ductal adenocarcinoma
NO performs its biological roles mainly through protein S-nitrosylation, but pathogenic roles of protein S-nitrosylation in PDAC remains largely unexplored. In this study, we identified large number of unique S-nitrosylation sites and proteins in PDAC patients and PANC-1 cells by a site-specific pro...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012512 | Pride
Pancreatic ductal adenocarcinoma Panc-1 S-nitrosoproteome 
TranscriptomicsThe nucleoid-associated protein HU controls three regulons that coordinate virulence and general physiology in Salmonella enterica serovar Typhimurium
The regulon of genes controlled by the HU nucleoid-associated proteins was examined in Salmonella enterica serovar Typhimurium (S. Typhimurium). DNA microarrays were used to detect the effect on the bacterial transcriptome of knockout mutations in the hupA, the hupB and in both the hupA and hupB gen...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2011-03-22 | E-GEOD-22860 | biostudies-arrayexpress
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