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ProteomicsBlocking TRIM47-mediated HNF4α degradation Suppress Hepatocellular Carcinoma Progression
Previous studies have highlighted the downregulation of hepatocyte nuclear factor 4α (HNF4α) as a critical event in the pathogenesis of HCC. However, the mechanism of its degradation in HCC remains unclear. Tripartite motif 47 (TRIM47), a typical E3 ubiquitin ligase of the TRIM family, implicates va...
ORGANISM(S): Homo Sapiens 
2025-04-01 | PXD062446 |
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
ProteomicsCandidate Arabidopsis MYB5-interacting proteins in developing siliques identified by IP-MS
2 g developing siliques were harvested from the pMYB5:MYB5-GFP/myb5-2 complementary plants treated with 100 μM GA3 or 50 μM PAC. The 35S:GFP transgenic plants served as a negative control. Siliques were immediately crosslinked with 1% paraformaldehyde for 30 min on ice in a vacuum chamber. Total pro...
ORGANISM(S): Arabidopsis Thaliana 
2025-03-27 | PXD062288 |
ProteomicsThe essential role of stress granules in cGAS sensing of DNA
cGAS-associated cellular proteins through performing co-immunoprecipitation (co-IP) followed by mass spectrometry and proteomic analysis
ORGANISM(S): Homo Sapiens 
2019-02-24 | PXD012847 |
TranscriptomicsDevelopment of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection
Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understand Mechanisms of Chemical Toxicity and Action These data support the publication titled "Development of a Large-Scale Chemogenomics Database to Improve Drug Candidate Selection and to Understa...
ORGANISM(S): Rattus norvegicus 
2005-05-31 | E-GEOD-2409 | biostudies-arrayexpress
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