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ProteomicsCharacterization of progressive denaturation and unfolding intermediates of proteins by fast cross-linking using di-ortho-phthalaldehyde
Chemical cross-linking of proteins coupled with mass spectrometry (CXMS) is widely used in protein structural analysis. In this study we develop a new class of non-hydrolyzable amine-selective di-ortho-phthalaldehyde (DOPA) cross-linkers, one of which is DOPA2. Cross-linking of proteins with DOPA2 i...
ORGANISM(S): Staphylococcus Aureus Bos Taurus 
2021-12-20 | PXD030552 |
TranscriptomicsPervasive TTP binding but selective target mRNA destabilization in the macrophage transcriptome [RNA-Seq_2]
Precise control of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. Parameters determining the specificity and extent of mRNA degradation within the entire inflammation-associated transcriptome remain incompletely understood. Using transcriptome-wide high...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-78209 | biostudies-arrayexpress
ProteomicsProtein ubiquitination in Aspergillus nidulans
Protein ubiquitination, an evolutionarily conserved post-translational modification process in eukaryotes, and plays an important role in many biological processes. Aspergillus nidulans, a model filamentous fungus, contributes to our understanding of cellular physiology, metabolism and genetics, but...
ORGANISM(S): Aspergillus 
2015-09-10 | PXD002299 | Pride
Lc-msms Aspergillus nidulans Ubiquitination Mycelial dvelopment 
TranscriptomicsCCRF-CEM Prednisolone treatment at 4h
Background: Glucocorticoids are important pharmaceutical agents in the treatment of acute lymphoblastic leukemia in children. Resistance or sensitivity to glucocorticoids is considered to be of crucial importance for disease prognosis. Prednisolone is a first-line chemotherapeutic agent in the treat...
ORGANISM(S): Homo sapiens 
2011-03-22 | E-GEOD-27989 | biostudies-arrayexpress
UnknownRepair mechanism of Wuwei Fuzheng Yijing formula in di-2-ethylhexyl phthalate-induced sperm DNA fragmentation in mice.
Not available
S-EPMC9272935 | biostudies-literature
TranscriptomicsmiRNA expression of human samples of hepatoblastoma (HB) and normal and fetal liver
Forty-nine hepatoblastoma (HB) tumor specimens were profiled on a microarray containing 250human miRNA, in order to identify miR classifiers that could discriminate HBs with diverse prognosis, and to get insight on the functional mechanisms in which miRNAs are involved. Hierarchical unsupervised clu...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-20971 | biostudies-arrayexpress
UnknownStreamlined Synthesis and Immunomodulatory Effects of Ulvan Oligosaccharides from Marine Green Algae.
Not available
S-EPMC12426931 | biostudies-literature
UnknownMCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise.
Not available
S-EPMC10856337 | biostudies-literature
TranscriptomicsIntestinal epithelial HuR balances counteracting RNA networks to protect against intestinal inflammation and cancer. PART 2 Differentiality in mRNA expression between Control mice and mice overexpressing Elavl1.
Elavl1/HuR is a ubiquitous and conserved RNA-binding protein that binds to a U-rich RNA motif that shuttles between nucleus and cytoplasm. In epithelia, the elevated expression of HuR assumingly promotes degeneration and cancer suggesting that its generic suppression may provide clinical benefits. I...
ORGANISM(S): Mus musculus 
2020-07-01 | E-MTAB-4017 | biostudies-arrayexpress
UnknownSymbiont-Driven Male Mating Success in the Neotropical Drosophila paulistorum Superspecies.
Not available
S-EPMC6327003 | biostudies-literature
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