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ProteomicsEndothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3
Understanding the molecular mechanisms of pathological vascular remodeling is important for treating cardiovascular diseases and complications. Recent studies have highlighted a role of deubiquitinases in vascular pathophysiology. In this study, we investigated the role of a deubiquitinase, OTUD1, i...
ORGANISM(S): Homo sapiens (Human) 
2022-12-24 | PXD037926 | Pride
Huvec  lc-ms/ms 
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Not available
S-EPMC6796393 | biostudies-literature
UnknownTargeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
Not available
S-EPMC11538459 | biostudies-literature
UnknownQingda granule prevents Ang II-induced cardiac hypertrophy via inhibiting NF-κB signaling pathway.
Not available
S-EPMC12479541 | biostudies-literature
UnknownMacrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Not available
S-EPMC10282045 | biostudies-literature
UnknownANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation.
Not available
S-EPMC4085534 | biostudies-literature
UnknownRoxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS.
Not available
S-EPMC8492313 | biostudies-literature
UnknownAnti-Inflammatory Effects of Ang-(1-7) in Ameliorating HFD-Induced Renal Injury through LDLr-SREBP2-SCAP Pathway.
Not available
S-EPMC4546194 | biostudies-literature
UnknownGasdermin D affects aortic vascular smooth muscle cell pyroptosis and Ang II-induced vascular remodeling
Not available
S-EPMC10248119 | biostudies-literature
UnknownAng II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro.
Not available
S-EPMC5506621 | biostudies-literature
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