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TranscriptomicsDNA damage responses and Mec1p
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the c...
ORGANISM(S): Saccharomyces cerevisiae 
2005-09-24 | E-GEOD-3358 | biostudies-arrayexpress
TranscriptomicsAirway Epithelial Cell Response to Sendai virus infection
Oligonucleotide microarrays were used to establish a profile for gene expression in wild-type airway epithelial cells after paramyxoviral infection. Analysis was performed on mRNA isolated from SeV-infected primary-culture mouse tracheal epithelial cells that were maintained under physiologic condit...
ORGANISM(S): Mus musculus 
2009-04-25 | E-GEOD-10211 | biostudies-arrayexpress
GenomicsChIPseq - The ETO2 scaffolding factor maintains acute leukemia by driving a MYB/EP300-dependent oncogenic program
Analysis of ETO2, MYB, EP300 binding as well as H3K27ac, H3K4me1 and H3M27me3 occupancy by ChIP-seq in HEL cells treated with DMSO or dCBP-1 (0.5uM) for 3h or expressing shRNA targeting MYB (shMYB) or genetically inactivated for ETO2 (ETO2ko)
ORGANISM(S): Homo sapiens 
2023-07-06 | E-MTAB-13151 | biostudies-arrayexpress
UnknownActivation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT.
Not available
S-EPMC10360396 | biostudies-literature
UnknownSTAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth.
Not available
S-EPMC6949402 | biostudies-literature
UnknownUncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody
Not available
S-SCDT-EMM-2021-14544 | biostudies-other
ModelsColitis-associated colon cancer
This model looks at the development of colitis-associated colon cancer in order investigate the mechanism behind inflammation-associated tumorigenesis. Dynamic simulations reveal that P53, MDM2, and AKT may constitute a core network responsible for the malignant transformation of colon epithelial ce...
4601 | Cell Collective
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