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MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
UnknownOlaparib promotes FABP4 expression and reduces antitumor effect in ovarian cancer cells with a BRCA1 mutation
Not available
S-EPMC11605280 | biostudies-literature
ProteomicsLRRK2-RAB12 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in Astrocytes
Leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of RAB GTPases and this phosphorylation is elevated by Parkinson’s disease (PD)-linked mutations of LRRK2. However, the precise function of the specific RAB GTPase targeted by LRRK2 signaling remains to be elucidated. Here we solve the str...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-18 | PXD048732 | Pride
Structure of lrrk2-rab12 protein complex Proteomics Lrrk2 Ciliogenesis Centrosome homeostasis Parkinson’s disease Tandem mass tag 
UnknownPPIP5K2 Facilitates Proliferation and Metastasis of Non-Small Lung Cancer (NSCLC) through AKT Signaling Pathway.
Not available
S-EPMC10854519 | biostudies-literature
ProteomicsIntegrated Structural and Glycoproteomic Profiling Reveals Protein Conformational Remodeling and Biomarkers Across Alzheimer’s Disease Progression
Alzheimer’s disease (AD) is characterized by progressive neurodegeneration and protein misfolding, yet the structural dynamics of proteins and their post-translational modifications during disease progression remain poorly understood. Here, we present an integrated structural and glycoproteomic anal...
ORGANISM(S): Homo sapiens (Human) 
2026-01-02 | PXD059280 | Pride
UnknownMicroplastic abundance in placental chorionic villi detected by pyrolysis-gas chromatography/mass spectrometry in cases of spontaneous miscarriage during early pregnancy.
Not available
S-EPMC12478273 | biostudies-literature
UnknownThe clinical and genomic distinctions of Class1/2/3 BRAF-mutant colorectal cancer and differential prognoses.
Not available
S-EPMC9875443 | biostudies-literature
ProteomicsMuscular lactate modulates phase transition-driven lactate body secretion to induce liver fibrosis during long-term overtraining
Exercise, as the fundamental therapy for metabolic diseases, often exhibits a dose-dependent fashion. However, the adverse effects of overtraining and underlying mechanisms remain unclear. Here, we show that long-term overtraining induces hepatic fibrosis in humans and mice. Mechanistically, excessi...
ORGANISM(S): Mus Musculus 
2024-05-21 | PXD052424 |
UnknownSafety and feasibility of laparoscopic surgery for colorectal and gastric cancer under the Chinese multi-site practice policy: admittance standards of competence are needed.
Not available
S-EPMC9522381 | biostudies-literature
UnknownFusobacterium nucleatum upregulates MMP7 to promote metastasis-related characteristics of colorectal cancer cell via activating MAPK(JNK)-AP1 axis.
Not available
S-EPMC10561506 | biostudies-literature
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