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TranscriptomicsEffect of T350 phosphorylation on gene repression activity of EZH2 in BJ cells
The Polycomb group (PcG) protein enhancer of zeste homolog 2 (EZH2) plays an essential role in histone methylation-mediated epigenetic gene silencing. We demonstrate that under physiological conditions, cyclin-dependent kinase 1 (CDK1) and 2 (CDK2) bind to and phosphorylate EZH2 at threonine 350 (T3...
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-22427 | biostudies-arrayexpress
TranscriptomicsEffects of T350 phospho- on gene repression activity of EZH2
The Polycomb group (PcG) protein enhancer of zeste homolog 2 (EZH2) plays an essential role in histone methylation-mediated epigenetic gene silencing. We demonstrate that under physiological conditions, cyclin-dependent kinase 1 (CDK1) and 2 (CDK2) bind to and phosphorylate EZH2 at threonine 350 (T3...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-20433 | biostudies-arrayexpress
TranscriptomicsEffects of Brca1 knock-down on Ezh2 targeting
The Polycomb repressive complex 2 (PRC2) is important for the maintenance of stem cell pluripotency and suppression of cell differentiation by promoting histone H3 lysine 27 trimethylation (H3K27me3) and silencing expression of genes regulating differentiation. Here we show decreased expression of B...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-37321 | biostudies-arrayexpress
ProteomicsA lncRNA from the FTO locus acts as an inhibitor of the m6A writer complex and p53 tumor suppression signaling
control RNA and FTO-IT1 RNA and their interacting proteins were pulled down by biotin-streptavidin beads to see the interacting protein of FTO-IT1 RNA.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD041053 | Pride
Fto-it1 Prostate cancer 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
ProteomicsSPOP mass spec in different treatment
293T cells were transfected with S, Flag, and Biotin-binding-protein-(streptavidin)-binding-peptide (SFB) triple-tagged backbone vector or SFB-tagged SPOP. Twenty-four h after transfection, control cells were treated with DMSO (Group 1) and SFB-SPOP transfected cells were treated with DMSO (Group 2)...
ORGANISM(S): Homo Sapiens 
2021-09-06 | PXD028210 |
ProteomicsN-glycopeptide Signatures in AFP-negative HCC
Serum N-linked intact glycopeptides was investigated in AFP-negative HCC and cirrhosis (LC) patients by using label-free quantification methodology.
ORGANISM(S): Homo Sapiens 
2021-01-11 | PXD023500 |
ProteomicsMass spectrometry identification of PPARγ methylation sites
Purified recombinant PPARγ-Flag and PRMT4-His were used for in vitro methyltransferase assay.We separated purified methylated PPARγ proteins by SDS-PAGE, visualized them by staining with Coomassie blue, protein lanes were cut into pieces about 1 mm3, and followed further destained.
ORGANISM(S): Homo Sapiens 
2022-06-27 | PXD034929 |
UnknownImmunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial.
Not available
S-EPMC10618459 | biostudies-literature
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