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UnknownNeutrophil-to-lymphocyte ratio predicts mortality for sepsis-induced coagulopathy: a retrospective study.

Background

Sepsis often leads to coagulation dysfunction, potentially progressing to disseminated intravascular coagulation (DIC), leading to higher mortality. Sepsis-induced coagulopathy (SIC), an early stage of DIC, benefits from early detection and intervention. Neutrophil-to-lymphocyte r...
S-EPMC12645672 | biostudies-literature
UnknownHeterogeneous impacts of carbohydrate subtypes on the progression of microvascular complications in hyperglycemic individuals: evidence from the UK biobank.

Background

Hyperglycemic individuals, who are prone to microvascular complications of diabetes (MCDs) like diabetic patients, may benefit from timely carbohydrate intake intervention. But there remain inconsistent results and lack of focus on carbohydrate subtypes, which may have distinct ef...
S-EPMC12797509 | biostudies-literature
UnknownSoluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy.
Obesity-driven cardiac lipid accumulation can progress to lipotoxic cardiomyopathy. Soluble epoxide hydrolase (sEH) is the major enzyme that metabolizes epoxyeicosatrienoic acids (EETs), which have biological activity of regulating lipid metabolism. The current study explores the unknown role of sEH...
S-EPMC8068623 | biostudies-literature
UnknownJAK inhibition as a new treatment strategy for patients with COVID-19.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic continues to spread globally. The rapid dispersion of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 drives an urgent need for effective treatments, especially for patients who develop severe pneumonia. The excessive...
S-EPMC9250821 | biostudies-literature
UnknownNLR stability predicts response to immune checkpoint inhibitors in advanced hepatocellular carcinoma.
A high baseline NLR is associated with a poor prognosis of immunotherapy in patients with advanced HCC. As anti-tumour immune activation takes time, early dynamic changes in NLR may serve as a biomarker for predicting immunotherapy response. We conducted a retrospective study in which we enrolled 20...
S-EPMC11344071 | biostudies-literature
UnknownModeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells.

Background

Amyotrophic lateral sclerosis (ALS) represents a devastating, progressive, heterogeneous, and the most common motor neuron (MN) disease. To date, no cure has been available for the condition. Studies with transgenic mice have yielded significant results that help us understand the...
S-EPMC6238404 | biostudies-literature
UnknownPhotothermal therapy of copper incorporated nanomaterials for biomedicine.
Studies have reported on the significance of copper incorporated nanomaterials (CINMs) in cancer theranostics and tissue regeneration. Given their unique physicochemical properties and tunable nanostructures, CINMs are used in photothermal therapy (PTT) and photothermal-derived combination therapies...
S-EPMC10675977 | biostudies-literature
UnknownIntegrated analysis of m6A regulator mediated RNA methylation and key immune related genes in ischemic stroke.
Not available
S-EPMC12394628 | biostudies-literature
UnknownThe role of postmastectomy radiation in patients with ypN0 breast cancer after neoadjuvant chemotherapy: a meta-analysis.

Background

It has been demonstrated that postmastectomy radiation therapy (PMRT) was beneficial for breast cancer patients who are axillary lymph node-positive. However, the effectiveness of radiotherapy in pathological negative nodes (ypN0) after neoadjuvant chemotherapy (NAC) remains open ...
S-EPMC8234630 | biostudies-literature
UnknownOleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways.
Hepatic ischemia-reperfusion (I/R) injury is a serious complication in patients who have undergone hepatic surgery such as orthotopic liver transplantation and partial hepatectomy. Recently, a new cytoprotective agent, ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE), was reported to protect ...
S-EPMC6930725 | biostudies-literature
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