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ProteomicsProteomic analysis of JF-305 derivative CPEB1 knockdown/overexpression cells
Pancreatic cancer is a leading cause of cancer death worldwide. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is a fundamental translation regulatory factor regulating the polyadenylation process of messenger RNA. However, its biological functions in pancreatic cancer are poorly unde...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD047241 | Pride
Pancreatic cancer Cpeb1 Lc-ms/ms 
ProteomicsEnzyme and Chemical Assisted N-Terminal Blocked Peptides Analysis, ENCHANT, as a Selective Proteomics Approach Complementary to Conventional Shotgun Approach
Shotgun (bottom-up) approach has been widely applied in large-scale proteomics studies. The inherent shortages of shotgun approach lie in that the generated peptides often overwhelm the analytical capacity of current LC-MS/MS systems and that abundant proteins often hamper the identification of prot...
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD007863 | Pride
Dia Single-charge ion inclusion N-terminal blocked peptides Cnbr-activated sepharose 4b 
ProteomicsThe development of a novel zeolite-based assay for efficient and deep plasma proteomic profiling
Plasma proteins are considered to be the most informative source of biomarkers for disease diagnosis and monitoring. Mass spectrometry (MS)-based proteomics has been applied to discover biomarkers in plasma, but the complexity of plasma proteins and the extremely large dynamic range of protein abund...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD048186 | Pride
Plasma Proteomic Protein corona Zeolite 
ProteomicsA DIA-based deep proteome profiling of Pseudomonas aeruginosa PAO1 reference strain under different growth conditions
We used the data-independent acquisition (DIA)-based quantitative proteomics to profile the abundance dynamics of proteins across different growth stages in P. aeruginosa PAO1 reference strain. Extensive modulations of protein expression levels were found in planktonic culture of PAO1 bacteria acros...
ORGANISM(S): Pseudomonas Aeruginosa Pao1 
2023-04-06 | PXD038460 |
Proteomicscapsaicin ameliorates rheumatoid arthritis via ROS-mediated apoptosis in fibroblast-like synoviocytes
In this project we discovered that CAP not only reduces joint swelling in arthritic model mice but also exhibits anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes (FLS). By synthesizing alkyne-tagged CAP probes and employing activity-based protein profiling (ABPP), we i...
ORGANISM(S): Homo Sapiens 
2024-11-07 | PXD057639 |
ProteomicsInhibition Peroxiredoxin-2 by capsaicin ameliorates rheumatoid arthritis via ROS-mediated apoptosis in fibroblast-like synoviocytes
In this project we discovered that CAP not only reduces joint swelling in arthritic model mice but also exhibits anti-inflammatory and antiproliferative effects on fibroblast-like synoviocytes (FLS). By synthesizing alkyne-tagged CAP probes and employing activity-based protein profiling (ABPP), we i...
ORGANISM(S): Homo Sapiens 
2024-11-12 | PXD057819 |
ProteomicsSEPHS2 loss reprograms cancer metabolism from oxidative phosphorylation to gluconeogenesis via PCK1 stabilization
SEPHS2, a key enzyme in synthesizing selenoproteins, which converts hydrogen selenide into selenophosphate. Here we provide the proteome of SEPHS2 knockout human A375 celllines.
ORGANISM(S): Homo Sapiens 
2026-03-25 | PXD076137 |
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