Huang Lijian L - OmicsDI

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Direct reprogramming of human fibroblasts to functional hepatocyte-like cells

Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (FOXA3, HNF1A and HNF4A), human fetal fibroblasts can be converted to hepatocyte-like cells (hiHep cells), expressing hepatic mar...

ORGANISM(S): Homo sapiens

2014-03-06 | E-GEOD-42643 | biostudies-arrayexpress

Conversion of mouse fibroblast to hepatocyte-like cells by defined factors

Plasticity of differentiated cells has been proved by nuclear transfer, induced pluripotent cells and transdifferentiation. Here we show that by transduction of 3 factors (Hnf1alpha, Gata4, and Foxa3) and p19Arf inactivation, tail-tip fibroblasts can be converted to hepatocyte-like (iHep) cells, exp...

ORGANISM(S): Mus musculus

2011-05-11 | E-GEOD-23635 | biostudies-arrayexpress

Prognostic value of serum vascular endothelial growth factor and hematological responses in patients with newly-diagnosed POEMS syndrome.

Not available

S-EPMC5884844 | biostudies-literature

What is the best first-line treatment for POEMS syndrome: autologous transplantation, melphalan and dexamethasone, or lenalidomide and dexamethasone?

Not available

S-EPMC6756085 | biostudies-literature

Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation.

Not available

S-EPMC5807361 | biostudies-literature

Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures.