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MetabolomicsTumor-derived L-arginine acts as a metabolic checkpoint to sustain CAR T cell anti-tumor memory

Metabolic competition within the tumor microenvironment (TME) severely impairs the efficacy and persistence of chimeric antigen receptor (CAR) T cells in solid tumors. While targeting tumor metabolism is a promising therapeutic avenue, its precise implementation remains a challenge. Here, we disc...

2026-10-23 | MTBLS14035 | MetaboLights
GenomicsMediator Complex Regulates Alternative mRNA Processing via the Med23 Subunit
Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its Med23 subunit. Combining tandem affinity purification and mass spectrometry, we identified a number of mRNA processing factors that bind to a soluble recomb...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-33887 | biostudies-arrayexpress
TranscriptomicsHost transcriptional reprogramming across diverse strains of the rice bacterial leaf streak pathogen Xanthomonas oryzae pv.oryzicola
We performed RNA-Seq of leaves of Oryza sativa L. ssp. japonica cv. Nipponbare 48 hours after inoculation with 10 geographically diverse strains of Xanthomonas oryzae pv. oryzicola, the causal agent of bacterial leaf streak. Results provide insight into the molecular basis of bacterial leaf streak, ...
ORGANISM(S): Oryza sativa Japonica Group 
2015-05-01 | E-GEOD-67588 | biostudies-arrayexpress
TranscriptomicsMediator Complex Regulates Alternative mRNA Processing via the Med23 Subunit
Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its Med23 subunit. Combining tandem affinity purification and mass spectrometry, we identified a number of mRNA processing factors that bind to a soluble recomb...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-33771 | biostudies-arrayexpress
UnknownMa Huang Tang ameliorates bronchial asthma symptoms through the TLR9 pathway.
Not available
S-EPMC6237163 | biostudies-literature
UnknownAntidepressant-Like Effects of GM1 Ganglioside Involving the BDNF Signaling Cascade in Mice.
Not available
S-EPMC5043648 | biostudies-literature
ProteomicsCDC-like Kinase 4 Deficiency Contributes to Pathological Cardiac Hypertrophy by Modulating NEXN Phosphorylation
Kinase-catalyzed phosphorylation plays crucial roles in numerous biological processes. CDC-like kinases (CLKs) are a group of evolutionarily conserved dual-specificity kinases that have been implicated in RNA splicing, glucose metabolism, diet-induced thermogenesis and so on. However, it is still la...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-05 | PXD029682 | Pride
Pathologic cardiac hypertrophy Cdc-like kinase 4 Phosphorylation Nexn 
UnknownRNA Interference-Mediated Knockdown of Bombyx mori Haemocyte-Specific Cathepsin L (Cat L)-Like Cysteine Protease Gene Increases Bacillus thuringiensis kurstaki Toxicity and Reproduction in Insect Cadavers.
Not available
S-EPMC9230843 | biostudies-literature
UnknownScreening of Antiviral Components of Ma Huang Tang and Investigation on the Ephedra Alkaloids Efficacy on Influenza Virus Type A.
Not available
S-EPMC6747051 | biostudies-literature
UnknownIntermodule Coupling Analysis of Huang-Lian-Jie-Du Decoction on Stroke.
Not available
S-EPMC6848980 | biostudies-literature
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