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ProteomicsBranched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC
Immunotherapy has revolutionized cancer treatment, however, a reliable biomarker is missing. MGAT5-mediated PD-L1 glycosylation is critical for its interaction with PD-1. MGAT5 expression is a functional biomarker that predicts immunotherapy responses.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045506 | Pride
Mgat5 Immunotherapy N-glycosylation Pd-l1 Head and neck squamous cell carcinoma (hnscc) 
ProteomicsTMTC1 promotes invasiveness of ovarian cancer
Ovarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Although O-mannosyltransferase TMTC1 is highly expressed by ovarian cancer, its pathophysiologic role in ovarian cancer remains unclear. Here, immunohistochemistry showed that TMTC1...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037907 | Pride
O-mannosylation Ovarian cancer Tmtc1 
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