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ProteomicsMGAT3 and MGAT5 overexpression alters the protein cargo of extracellular vesicles released by metastatic melanoma cells
Extracellular vesicles (EVs) are potential non-invasive diagnostic, prognostic, and therapeutic tools. Additionally, they are important contributors to tumorigenesis. Glycosylation has been found to modulate the composition of the EV proteome, and increased amounts of beta 1,6-branched N-glycans, sy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-08 | MSV000096340 | MassIVE
ProteomicsBranched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC
Immunotherapy has revolutionized cancer treatment, however, a reliable biomarker is missing. MGAT5-mediated PD-L1 glycosylation is critical for its interaction with PD-1. MGAT5 expression is a functional biomarker that predicts immunotherapy responses.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045506 | Pride
Mgat5 Immunotherapy N-glycosylation Pd-l1 Head and neck squamous cell carcinoma (hnscc) 
UnknownHydrogen Sulfide Demonstrates Promising Antitumor Efficacy in Gastric Carcinoma by Targeting MGAT5.
Not available
S-EPMC6041565 | biostudies-literature
UnknownN-glycosylation by Mgat5 imposes a targetable constraint on immune-mediated tumor clearance.
Not available
S-EPMC11383181 | biostudies-literature
UnknownRegulation of neural stem cell differentiation and brain development by MGAT5-mediated N-glycosylation.
Not available
S-EPMC10277816 | biostudies-literature
GenomicsExpression profile of Mgat5 knockout (CRISPR-Cas9) in murine colon adenocarcinoma cells (MC38)
Expression profile of Mgat5 knockout (CRISPR-Cas9) in murine colon adenocarcinoma cells (MC38)
PRJNA1468701 | ENA
UnknownThe polymorphisms of FGFR2 and MGAT5 affect the susceptibility to COPD in the Chinese people.
Not available
S-EPMC8058990 | biostudies-literature
UnknownGlioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing.
Not available
S-EPMC8067292 | biostudies-literature
UnknownLoss of Barx1 promotes hepatocellular carcinoma metastasis through up-regulating MGAT5 and MMP9 expression and indicates poor prognosis.
Not available
S-EPMC5641096 | biostudies-literature
UnknownN-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation.
Not available
S-EPMC11545198 | biostudies-literature
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