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ProteomicsTargeting IFN-γ-inducible lysosomal thiol reductase Overcomes Chemoresistance in AML through Regulating the ROS-mediated mitochondrial damage
Our work demonstrated that the inhibition of GILT increases AML chemo-sensitivity through elevating ROS level and induce oxidative mitochondrial damage-mediated apoptosis, and inhibition of the PI3K/Akt/NRF2 pathway enhances the intracellular oxidative state by disrupting redox homeostasis. Our stud...
ORGANISM(S): Homo Sapiens 
2021-03-31 | PXD025114 |
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
ProteomicsLenalidomide-induced pure red cell aplasia analysis
The RVd therapy, combining lenalidomide, bortezomib, and dexamethasone, is a mainstay treatment for multiple myeloma. A multiple myeloma patient developed pure red cell aplasia (PRCA) following RVd treatment, despite the absence of common PRCA triggers. In vitro analyses revealed lenalidomide as a p...
ORGANISM(S): Homo Sapiens 
2024-09-03 | PXD055495 |
ProteomicsMorphological change of gill and activation of cell phagocytosis pathway through differential proteomics in Mytilus coruscus under starvation
Mytilus coruscus are one of the dominant shellfish in the Yangtze estuary, but they often face food deprivation due to seasonal fluctuations in algal abundance caused by seasonal freshwater flushing and high-density aquaculture. To investigate the coping strategies of M. coruscus to starvation stres...
ORGANISM(S): Mytilus Coruscus 
2023-03-16 | PXD040908 |
Proteomicsproteomic signature to predict ACT in CRC
High-throughput proteomics profiling-derived signature associated with chemotherapy response and survival for stage II/III colorectal cancer
ORGANISM(S): Homo Sapiens 
2023-06-19 | PXD043116 |
ProteomicsBRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK
Erythropoiesis is a crucial part in hematopoietic system, while facing disruptions from various diseases conditions. Anemia and blood shortages has become global challenges, with current finite pharmacological options like EPO or glucocorticoids having limitations, especially in genetic anemias like...
ORGANISM(S): Homo Sapiens 
2024-09-09 | PXD055730 |
UnknownIntegrative annotation of variants from 1092 humans: application to cancer genomics.
Not available
S-EPMC3947637 | biostudies-literature
UnknownA global reference for human genetic variation.
Not available
S-EPMC4750478 | biostudies-literature
UnknownAn integrated map of genetic variation from 1,092 human genomes.
Not available
S-EPMC3498066 | biostudies-literature
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