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MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
ProteomicsIntegrated transcriptomic and proteomic analysis reveals Runx2b-associated molecular regulation of intermuscular bone development in Culter alburnus
This dataset contains LC-MS/MS-based proteomic data generated from muscle/myoseptal tissues of wild-type, heterozygous runx2b mutant, and homozygous runx2b mutant Culter alburnus individuals. The study aimed to characterize proteomic changes associated with runx2b-mediated intermuscular bone reducti...
ORGANISM(S): Culter alburnus 
2026-09-07 | PXD080591 | Pride
Culter alburnus  intermuscular bone  runx2b  proteomics  dia  lc-ms/ms  gene editing  skeletal development  muscle/myoseptal tissue 
ProteomicsLncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells
LC-MS/MS combined with the ChIRP for the mESCs of WT and lncRNA-Smad7 KO
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD036394 | Pride
Mouse lc-ms/ms mescs chirp 
ProteomicsPotential binding proteins of CAV3 obtained from LC-MS/MS
To gain further insight into the molecular mechanisms of CAV3 in DCM. we conducted liouid chromatography-tandem mass spectrometry (LC-MS/MSassays to identify potential binding proteins of CAV3 in cardiomyocytes.LC-MS/MS was conducted by SpecAly Life Technology Co, Ltd. (Wuhan, China).
ORGANISM(S): Homo Sapiens 
2023-08-21 | PXD044674 |
ProteomicsBacterial Protoplast-Derived Nanovesicles Carrying CRISPR Cas9 Tools Efficiently Re-educate Tumor-Associated Macrophages for Cancer Immunotherapy
we developed an in vivo CRISPR-Cas9 genome editing system that targets tumor-associated macrophages (TAMs) via bacterial protoplast-derived nanovesicles (NVs) decorated with a pH-responsive PEG conjugated polymer and galactosamine-conjugated ligand
ORGANISM(S): Escherichia Coli Bl21(de3) 
2023-09-20 | PXD045507 |
ProteomicsProteomic Analysis of Spermathecal Fluid in Amphioctopus fangsiao: Molecular Insights into Long-Term Sperm Storage
Amphioctopus fangsiao is an economically important cephalopod species in northern China. A notable reproductive adaptation of this species is the prolonged storage of sperm in the female spermatheca for up to 8 months post-mating, until oocyte maturation and release. Spermathecal fluid, as a critica...
ORGANISM(S): Amphioctopus Fangsiao 
2025-11-20 | PXD071105 |
ProteomicsMurine osteoblast, supernatant and serum mass spectrometry analysis
Mass spec data of murine osteoblast, serum and supernatant
ORGANISM(S): Mus Musculus 
2024-07-25 | PXD054258 |
ProteomicsProteomics of the Gastric cancer Response to Chemotherapy
Herein, we set out to investigate the responses to first-line therapies (DOS, XELOX, and anti-HER2-based therapies) for GC through a comprehensive proteomic analysis. We constructed a GC cohort that covered three clinical therapy subcohorts, including a DOS subcohort (44 patients treated with DOS th...
ORGANISM(S): Homo Sapiens 
2022-09-09 | PXD024255 |
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