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ProteomicsDefining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding
NSD2 is a histone methyltransferase that specifically dimethylates histone H3 lysine 36 (H3K36me2), a modification associated with gene activation. Dramatic overexpression of NSD2 in t(4;14) multiple myeloma (MM) and an activating mutation of NSD2 discovered in acute lymphoblastic leukemia (ALL) are...
ORGANISM(S): Homo sapiens (Human) 
2019-06-27 | PXD013759 | Pride
Interacting partners Label-free proteomics Nsd2 Bioid Multiple myeloma Lc-ms/ms 
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
ProteomicsChronic Stress Induced and Tumor Derived SP1+ exosomes Polarizing IL-1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer
We collected tumor-derived exosomes of 4T1 tumor-bearing mice in the control group and the stress group.
ORGANISM(S): Mus Musculus 
2023-12-26 | PXD048125 |
ProteomicsPramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation
Interactome of Pramel15-Flag in TT2 mESCs, two biologocal replicates
ORGANISM(S): Mus Musculus 
2024-06-11 | PXD052998 |
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