Sort   by:  
 Page size 
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming
This SuperSeries is composed of the following subset Series: GSE29146: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP] GSE29147: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi] GSE29148: NSD2 links dimethylation of histone H3 at...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29305 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [TKO]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29148 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29147 | biostudies-arrayexpress
GenomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29146 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [Transduction]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Mus musculus 
2011-11-29 | E-GEOD-29150 | biostudies-arrayexpress
ProteomicsDefining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding
NSD2 is a histone methyltransferase that specifically dimethylates histone H3 lysine 36 (H3K36me2), a modification associated with gene activation. Dramatic overexpression of NSD2 in t(4;14) multiple myeloma (MM) and an activating mutation of NSD2 discovered in acute lymphoblastic leukemia (ALL) are...
ORGANISM(S): Homo sapiens (Human) 
2019-06-27 | PXD013759 | Pride
Interacting partners Label-free proteomics Nsd2 Bioid Multiple myeloma Lc-ms/ms 
ProteomicsNSD2 promotes HCC metastasis through methylating PKM2 and activating SF3B1-dependent alternative splicing
Hepatocellular carcinoma (HCC) is notorious for its early and frequent metastases. To understand the molecular mechanisms underlying HCC metastasis, we generated a pulmonary metastasis HCC mouse model and performed both time-series transcriptomics and proteomics analysis of protein methylation. We f...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD056689 | Pride
Lactylation Sf3b1 Methylation Nsd2 Pkm2 
ProteomicsNSD2 promotes HCC metastasis through methylating PKM2 and activating SF3B1-dependent alternative splicing
Hepatocellular carcinoma (HCC) is notorious for its early and frequent metastases. To understand the molecular mechanisms underlying HCC metastasis, we generated a pulmonary metastasis HCC mouse model and performed both time-series transcriptomics and proteomics analysis of protein methylation. We f...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD056679 | Pride
Lactylation Sf3b1 Methylation Nsd2 Pkm2 
ProteomicsNSD2 promotes HCC metastasis through methylating PKM2 and activating SF3B1-dependent alternative splicing
Hepatocellular carcinoma (HCC) is notorious for its early and frequent metastases. To understand the molecular mechanisms underlying HCC metastasis, we generated a pulmonary metastasis HCC mouse model and performed both time-series transcriptomics and proteomics analysis of protein methylation. We f...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD056672 | Pride
Lactylation Sf3b1 Methylation Nsd2 Pkm2 
ProteomicsNSD2 promotes HCC metastasis through methylating PKM2 and activating SF3B1-dependent alternative splicing
Hepatocellular carcinoma (HCC) is notorious for its early and frequent metastases. To understand the molecular mechanisms underlying HCC metastasis, we generated a pulmonary metastasis HCC mouse model and performed both time-series transcriptomics and proteomics analysis of protein methylation. We f...
ORGANISM(S): Homo sapiens (Human) 
2025-09-30 | PXD056676 | Pride
Lactylation Sf3b1 Methylation Nsd2 Pkm2 
Sort   by:  
 Page size