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ProteomicsMining novel gene targets for improving tolerance to furfural and acetic acid in Yarrowia lipolytica using whole-genome clustered regularly interspaced short palindromic repeats interference library
In this study, a whole-genome CRISPRi library was developed in Y. lipolytica and applied for enforcing the tolerance to furfural and acetic acid. Several novel gene targets were discovered through NGS before and after screening. And to analyze the tolerance mechanism caused by transcriptional repres...
ORGANISM(S): Yarrowia Lipolytica 
2024-03-31 | PXD051116 |
ProteomicsGenome-scale CRISPRi screen identifies pcnB repression conferring overproduction of free fatty acids in Escherichia coli
In this study, we carried out genome-scale CRISPRi modulation combining fluorescence-activated cell sorting (FACS) and next-generation sequencing (NGS) to identify genetic determinants for FFAs overproduction in Escherichia coli. The pcnBi (AP) strain that repressed the expression of pcnB produced 2...
ORGANISM(S): Escherichia Coli 
2024-05-18 | PXD052390 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-04 | PXD072640 |
ProteomicsCRL4AMBRA1 mediated progesterone receptor degradation drives progestin resistance and represents a therapeutic vulnerability in endometrial cancer
AMBRA1 ubiquitinates PR to ptomote progestin resistance in endometrial cancer
ORGANISM(S): Homo Sapiens 
2026-01-08 | PXD072904 |
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