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TranscriptomicsTranscriptome profile of peripheral blood mononuclear cells in patients with type I diabetes and their first grade relatives
Type 1 Diabetes (T1D) is considered to be a Th1 autoimmune disease characterised by an absolute lack of insulin caused by an autoimmune destruction of the insulin producing pancreatic beta cells. Th1 lymphocytes are responsible for the infiltration of the islets of Langerhans and for the cytokine re...
ORGANISM(S): Homo sapiens 
2011-05-09 | E-GEOD-29142 | biostudies-arrayexpress
ProteomicsMitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice
Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies have prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochondrially targeted tamoxifen, a potential anti-canc...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD031710 | Pride
Obesity Mice Mitochodnria Tamoxifen 
TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
UnknownDynamic alterations of bone marrow cytokine landscape of myelodysplastic syndromes patients treated with 5-azacytidine.
Not available
S-EPMC5087287 | biostudies-literature
UnknownReplication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors.
Not available
S-EPMC7007433 | biostudies-literature
UnknownRadiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells.
Not available
S-EPMC4423190 | biostudies-literature
UnknownTargeting Mitochondrial Integrity as a New Senolytic Strategy.
Not available
S-EPMC12539531 | biostudies-literature
UnknownAberrantly elevated suprabasin in the bone marrow as a candidate biomarker of advanced disease state in myelodysplastic syndromes.
Not available
S-EPMC7530796 | biostudies-literature
UnknownTopological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment.
Not available
S-EPMC11466457 | biostudies-literature
UnknownComplex Positive Effects of SGLT-2 Inhibitor Empagliflozin in the Liver, Kidney and Adipose Tissue of Hereditary Hypertriglyceridemic Rats: Possible Contribution of Attenuation of Cell Senescence and Oxidative Stress.
Not available
S-EPMC8508693 | biostudies-literature
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