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ProteomicsComparison of the reactivity of hypochlorous acid (HOCl) and hyposelenocyanous acid (HOSeCN) with elastase: role of amino acid modification and structural changes in loss of activity.
Elastase is a serine protease that plays a key role in intracellular and extracellular neutrophil-driven immune responses. There is a synergistic relationship between elastase and myeloperoxidase (MPO), which can boost pathogen killing and limit collateral proteolytic damage to host tissue. However,...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-06-22 | PXD075502 | Pride
Inflammation Protease Protein oxidation Selenocyanate Myeloperoxidase 
ProteomicsSelective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept
Prospective discovery of molecular glues degraders for a specific therapeutic target protein of interest is an emerging strategy in drug discovery. Modification of pre-existing ligands with fragments that can alter the protein surface can lead to the creation of novel compounds (‘’targeted glues’’)...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD062354 | Pride
Global proteomics Orbitrap fusion™ lumos™ tribrid™ Tmt Mv411 
ProteomicsSelective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept
Prospective discovery of molecular glues degraders for a specific therapeutic target protein of interest is an emerging strategy in drug discovery. Modification of pre-existing ligands with fragments that can alter the protein surface can lead to the creation of novel compounds (‘’targeted glues’’)...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD062355 | Pride
Tmt Hek293 ip-ms 
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