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ProteomicsQuantitative proteomics and in-cell cross-linking reveal cellular reorganisation during early neuronal differentiation of SH-SY5Y cells
The proteomes of undifferentiated and differentiated SH-SY5Y cells are characterised and compared. For this, neuronal differentiation using retinoic acid (RA) or a combination of RA and phorbol-12-myristat-13-acetate (RA/PMA) was explored. An MS-based label-free quantification approach is applied to...
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD031054 | Pride
Proteomics Chemical cross-linking Mass spectrometry Protein networks Actin Sh-sy5y 
TranscriptomicsMutual Antagonistic Relationship Between Prostaglandin E2 and Interferon-(gamma): Implications for Rheumatoid Arthritis
PGE2 is a major mediator of inflammation and is present at high concentrations in the synovial fluid of rheumatoid arthritis (RA) patients. PGE2, acting through the EP4 receptor, has both pro- and anti-inflammatory roles in vivo. To shed light on this dual role of PGE2, we investigated its effects ...
ORGANISM(S): Homo sapiens 
2008-05-29 | E-GEOD-11575 | biostudies-arrayexpress
TranscriptomicsA Comparison of microarray and MPSS Technology Platforms for Expression Analysis of Arabidopsis
A comparison of microarray and MPSS technologies can help to establish the metrics for data comparisons across these technology platforms and determine some of the factors affecting the measurement of mRNA abundances using different platforms. Here, different Treatments/Conditions based on differen...
ORGANISM(S): Arabidopsis thaliana 
2007-09-14 | E-GEOD-8994 | biostudies-arrayexpress
TranscriptomicsComparative Transcriptomics of Soybean Near Isogenic Lines in Response to Phytophthora Sojae
Phytophthora root and stem rot (PRR) of soybean, caused by Phytophthora sojae, is effectively controlled by Rps genes in soybean. Rps genes are race-specific, yet the mechanism of resistance, as well as susceptibility, remains largely unclear. Taking advantage of RNA-seq technology, we sequenced the...
ORGANISM(S): Glycine max 
2014-04-16 | E-GEOD-48524 | biostudies-arrayexpress
UnknownRA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients.
Not available
S-EPMC9085807 | biostudies-literature
UnknownAssociation between body weight and tocilizumab effectiveness in rheumatoid arthritis: results from the BSRBR-RA.
Not available
S-EPMC11781575 | biostudies-literature
UnknownAnatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.
Not available
S-EPMC21274 | biostudies-literature
UnknownA C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.
Not available
S-EPMC21104 | biostudies-literature
ProteomicsMatrix-mediated activation of fibroblasts in rheumatoid arthritis
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting synovial joints and leading to cartilage damage and bone loss. This destruction is promoted by activated fibroblast-like synoviocytes (FLS) that show an invasive and migratory phenotype. The mechanisms of FLS activation are un...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-14 | PXD049800 | Pride
Chondrocytes Cytokines Fibroblast-like synoviocytes Extracellular matrix 
MetabolomicsNMR based metabolomics study of Y2 receptor activation by neuropeptide Y in the SK-N-BE2 human neuroblastoma cell line
Neuropeptide Y (NPY) and its Y2 receptors (Y2R) play an important role in regulating growth of various tumors and are highly expressed in human neuroblastoma brain tumors. Cell lines derived from neuroblastoma brain tumors provide a good model to study the consequences of NPY activation of Y2R in tu...
2014-10-01 | MTBLS104 | MetaboLights
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