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TranscriptomicsGenome-wide analysis of FSH and LH dependent gene expression and the crosstalk between these two pathways in mice testes
Effects of the absence of a functional LH receptor and/or expression of a constitutively active FSH receptor on gene expression in the gonads of male mice were studied. The results provide insights into the roles of the hormones LH and FSH in male reproduction. The main conclusion is that constant s...
ORGANISM(S): Mus musculus 
2016-01-20 | E-GEOD-76945 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gonadotropin-dependent gene expression and crosstalk of the regulatory pathways in the female ovaries
Effects of lack of functional LH receptor and/or a constitutively active FSH receptor on gene expression in the ovaries of female mice were studied. The results suggest that transgenic expression of the mouse Fshr in granulosa cells leads to abnormal ovarian structure/function and infertility. This ...
ORGANISM(S): Mus musculus 
2016-02-03 | E-GEOD-77479 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse leydig tumor cell line stimulated with either human chorionic gonadotropin alone or with bisphenol A, an endrocrine disrupting chemical
A mouse leydig tumour cell line (mLTC-1) was grown in culture and stimulated with either human chorionic gonadotropin (hCG, 10 ng/ml) alone or hCG & bisphenol A (BPA, an endrocrine disrupting chemical, 10 uM) for three hours. Cells from triplicate plates were harvested, RNA extracted, labelled and ...
ORGANISM(S): Mus musculus 
2008-01-01 | E-MIMR-282 | biostudies-arrayexpress
TranscriptomicsEstrogen regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation
Despite numerous observations of effects of estrogens on spermatogenesis, identification of estrogen-regulated genes in the testis is limited. We previously showed in rats, in which irradiation had completely blocked spermatogonial differentiation, that testosterone (T) suppression with GnRH-antagon...
ORGANISM(S): Rattus norvegicus 
2011-11-22 | E-GEOD-24672 | biostudies-arrayexpress
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