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MetabolomicsA comprehensive multiomic analysis reveals metabolic reprogramming underlying human Fontan-associated liver disease

BACKGROUND: Single ventricle congenital heart disease (SVCHD) is a severe form of cardiac malformation in which there is only one functional ventricle. The Fontan operation is the current standard of care for SVCHD. Almost all patients who have undergone the Fontan operation develop liver fibrosi...

2024-12-13 | MTBLS10782 | MetaboLights
TranscriptomicsMolecular analysis of clonal B cells in hepatitis C virus related-lymphoproliferation
Comparison of molecular pathways in clonal and non-clonal marginal zone B cells in Hepatitis C virus patients
ORGANISM(S): Homo sapiens 
2011-02-15 | E-MTAB-521 | biostudies-arrayexpress
TranscriptomicsGene expression profiles regulated by Stat5a/b vs. Stat3 in human prostate cancer cells.
Identification of the molecular changes that promote viability and metastatic behaviour of prostate cancer cells is critical for the development of improved therapeutic interventions for prostate cancer. Stat5a/b and Stat3 are both constitutively active in locally-confined and advanced prostate canc...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-17482 | biostudies-arrayexpress
ProteomicsCyclophilin B function elucidated by electrochemical sensors
We have investigated the function of CypB through negative ionization high resolution LCMS and examined the purity of a CypB protein with intact mass analyzes on a Q Exactive mass spectrometer.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-19 | MSV000089498 | MassIVE
TranscriptomicsGenome-wide midrange transcription profiles reveal expression level relationships in human tissue specification - GeneNote
PolyA+ RNA samples from the twelve healthy human tissues were purchased from Clontech (Palo Alto, CA). Each RNA sample is typically composed of a pool of 10-25 individuals. The expression intensity of mRNA was assayed across five microarrays (Affymetrix GeneChips U95A–E). Please note GeneNote is now...
ORGANISM(S): Homo sapiens 
2003-11-19 | E-GEOD-803 | biostudies-arrayexpress
ProteomicsProteomic analysis of donor and cardiomyopathy pre-mortem human hearts
Our understanding of heart failure (HF) has been provided by indirect surrogates, such as post-mortem histology, cardiovascular imaging, and molecular characterisation in vivo and in vitro, rather than directly in pre-mortem human cardiac tissue. Using our heart bank of pre-mortem hearts procured ac...
ORGANISM(S): Homo sapiens (Human) 
2023-05-18 | PXD014826 | Pride
Cardiovascular disease Human heart Cardiomyopathy 
MetabolomicsNicotinamide Riboside is Uniquely Bioavailable in People and Mice
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we conducted experiments to determine the time and dose-dependent effects of NR on blood, liver and heart NAD+ metabolism in people and mice. We report that human blood cell NAD+ can rise as much as 2.7-fold with a single d...
2016-09-09 | MTBLS368 | MetaboLights
ProteomicsNext-generation Serology by Mass Spectrometry:Readout of the SARS-CoV-2 Antibody Repertoire
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy chains. Ig-MS uses new advances i...
ORGANISM(S): Homo Sapiens 
2022-09-24 | PXD028627 | panorama
ProteomicsProteomic analysis of ischemic and dilated cardiomyopathy pre-mortem human hearts
Our understanding of heart failure (HF) has been provided by indirect surrogates, such as post-mortem histology, cardiovascular imaging, and molecular characterisation in vivo and in vitro, rather than directly in pre-mortem human cardiac tissue. Using our heart bank of pre-mortem hearts procured ac...
ORGANISM(S): Homo sapiens (Human) 
2020-05-01 | PXD018678 | Pride
Ischemic cardiomyopathy Myocardium Dilated cardiomyopathy 
no omics definedTranscription profiling of human Vg9/Vd2 T cells after 72h stimulation with HMB-PP in the presence of IL-2, IL-4, or IL-21
Hver2.1.1 microarrays containing ~15,000 genes were used to characterize the gene expression profiles of Vg9/Vd2 T cells upon 72h stimulation with HMB-PP in the presence of IL-2, IL-4, or IL-21.
ORGANISM(S): Homo sapiens 
2007-03-21 | E-MEXP-763 | biostudies-arrayexpress
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