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MetabolomicsGPR109a-AMPK Axis Mediates the Attenuation of Uric Acid-Induced M1 Macrophage Polarization by β-hydroxybutyrate from Lacticaseibacillus rhamnosus M2b

Hyperuricemia (HUA) is a metabolic disorder marked by increased blood uric acid (UA) levels, closely linked to conditions such as gout. UA-induced macrophage M1 polarization fundamentally exacerbates inflammatory pathophysiology, but current HUA-specific immunoregulatory treatments are inadequat...

2026-01-26 | MTBLS13224 | MetaboLights
ProteomicsA2M Q975C and C3 Q1013C disulfide mutants
Mutant A2M and C3 with disulfides replacing their thiol esters were disulfide mapped via pepsin digests.
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD019082 | Pride
Human c3 a2m 
ProteomicsA2M-3K DSSO cross-linking to identify the bait region position
An A2M mutant, A2M-3K, with the bait region arginines replaced with lysines, was cross-linked with DSSO. Its monomeric gel band was analyzed by XL-MS to identify the bait region position within a subunit.
ORGANISM(S): Homo sapiens (Human) 
2021-05-21 | PXD019048 | Pride
Human a2m 
ProteomicsA2M Thr654Cys Thr661Cys mutant disulfide mapping
The Thr654Cys and Thr661Cys mutations were used to introduce a disulfide bridge into the interacting LNK domains of human A2M. In this study, formation of the disulfide was investigated by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2021-05-21 | PXD019081 | Pride
Human a2m disulfide mutant 
ProteomicsCX-MS of DSSO-cross-linked A2M - Structural investigations of human α2-macroglobulin elucidate its native conformation and inhibitory mechanism
Human A2M was cross-linked with DSSO in its native, methylamine-treated, and trypsin-cleaved conformations. The monomer, dimer, and tetramer SDS-PAGE gel bands of native A2M were analyzed by in-gel digest. Total protein digests of all three conformations were analyzed and compared.
ORGANISM(S): Homo sapiens (Human) 
2021-05-21 | PXD019101 | Pride
Human a2m dsso 
TranscriptomicsExpression data from human CD34+ HPC subpopulations transduced with nuclear-trapped AF1q/MLLT11 (A2M)
We used microarrays to examine the impact of AF1q/MLLT11 on the gene expression profile of CD34+CD45RA-Lin- and CD34+CD45RA+Lin- HPCs isolated from umbilical cord blood CD34+CD45RA-Lin- and CD34+CD45RA+Lin- HPCs correspond respectively to early multipotent and lympho-granulo-macrophagic precursors. ...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-29523 | biostudies-arrayexpress
ProteomicsA2M bait region engineering - autoconjugation product cross-link identification and PRM quantification
In-gel digest of a cross-linked product band was used to identify an internal isopeptide cross-link formed in A2M TR K704 upon bait region cleavage by trypsin. PRM was used to quantify the thiol ester in native PAGE bands of A2M nEXT and EXT mutants.
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023651 | Pride
Prm Protease inhibitor Protein engineering Cross-link A2m 
TranscriptomicsExpression data from Notch-activated CD34+CD45RA-Lin- hematopoietic progenitor cells (HPCs) transduced with nuclear-trapped AF1q/MLLT11 (A2M)
We used microarrays to examine the impact of AF1q/MLLT11 on the gene expression profile of Notch-activated CD34+CD45RA-Lin- HPCs isolated from umbilical cord blood CD34+CD45RA-Lin- HPCs correspond to early multipotent progenitors. A2M is a nuclear mutant derivative of AF1q/MLLT11 CD34+CD45RA-Lin- H...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-29524 | biostudies-arrayexpress
GenomicsInvestigate A2M treatment on human prostate cancer xenograft in mice
Investigate A2M treatment on human prostate cancer xenograft in mice
PRJNA418738 | ENA
TranscriptomicsInvestigate A2M treatment on human prostate cancer xenograft in mice
Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contribute to the naked mole-rat’s cancer resistance. N...
ORGANISM(S): Homo sapiens 
2018-01-25 | GSE106989 | GEO
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