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TranscriptomicsPhenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus
We report the application of RNA sequencing technology for high-throughput profiling of gene expression responses to human rhinovirus infection at 24 hours in air-liquid interface human airway epithelial cell cultures derived from 6 asthmatic and 6 non-asthmatic donors. RNA-seq analysis identified ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-61141 | biostudies-arrayexpress
TranscriptomicsEffects of Myb shRNA on Airway Epithelial Cells
The epithelium of the pulmonary airway is specially differentiated to provide defense against environmental insults, but also subject to dysregulated differentiation that results in lung disease. The current paradigm for airway epithelial differentiation is a one-step program whereby a p63+ basal ep...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60365 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelial cells before and after segmental allergen challenge to identify effects of allergen challenge on airway epithelial cell gene expression
Allergen exposure induces the airway epithelium to produce chemoattractants, proallergic interleukins, matrix-modifying proteins, and proteins that influence the growth and activation state of airway structural cells. These proteins, in turn, contribute to the influx of inflammatory cells and change...
ORGANISM(S): Homo sapiens 
2007-11-21 | E-GEOD-3004 | biostudies-arrayexpress
TranscriptomicsGene Expression Effects of IL-13 on Primary Human Airway Epithelial Cells
Primary culture airway epithelial cells, grown under physiologic air-liquid interface conditions, with, or without IL-13 in order to study the effects of this cytokine on mucous cell metaplasia, an important feature of asthma and COPD. Keywords: IL13, mucus, goblet cell RNA was isolated from primary...
ORGANISM(S): Homo sapiens 
2012-12-04 | E-GEOD-37693 | biostudies-arrayexpress
ProteomicsMetabolic reprogramming in the airway epithelium of high risk individuals
We investigated proteins identified by shotgun proteomics in cytologically normal airway epithelial cells from individuals at different levels of risk for lung cancer. We identified 2869 proteins in bronchial brushings from individuals at low, moderate or high risk for lung cancer. Pathway analysis ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000079331 | MassIVE
TranscriptomicsTranscription profiling of human airway epithelial cell-conditioned monocyte-derive dendritic cells
Dendritic cells differentiate from their precursors in the airway mucosa under local environmental instruction. Airway epithelial cells (AEC) are a potent source of both pro- and anti-inflammatory mediators and are in intimate contact with intraepithelial DC and their precursors. Thus, AEC are like...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12773 | biostudies-arrayexpress
TranscriptomicsDo Airway Epithelium Air-liquid Cultures Represent the In Vivo Airway Epithelium Transcriptome?
Human airway epithelial cells cultured in vitro at air-liquid interface (ALI) form a pseudostratified epithelium that forms tight junctions and cilia, and produces mucin, and are widely used as a model of differentiation, injury, and repair. To assess how closely the transcriptome of ALI epithelium ...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-18637 | biostudies-arrayexpress
GenomicsMultiple roles for Grainyhead-like transcription factors in the establishment and maintenance of human mucociliary airway epithelium (ChIP-Seq)
The airways of the human lung are lined by an epithelium made up of ciliated and secretory luminal cells and undifferentiated p63+ Krt5+ basal cells. The integrity of this epithelium and its ability to act as a selective barrier are critical for normal lung function. In other epithelia there is evid...
ORGANISM(S): Homo sapiens 
2013-05-07 | E-GEOD-46194 | biostudies-arrayexpress
TranscriptomicsInfection of the larval airway epithelium by Erwinia carotovora
The unsurpassed simplicity of the fruitfly’s airway epithelium, that is made of homogenous epithelial cells only, favours its use as a model to study general features and response characteristics of airway epithelia in general. All epithelial cells are able to launch an immune response as characte...
ORGANISM(S): Drosophila melanogaster 
2010-05-19 | E-GEOD-11444 | biostudies-arrayexpress
ProteomicsSystematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights Into Pathogenesis Of RSV-Induced Lower Respiratory Tract Infections
Lower respiratory tract infections (LRTI) from human Respiratory Syncytial Virus (RSV) are a significant cause of morbidity in children. A component of LRTI pathogenesis is due to signals generated by infected lower airway cells that alter lymphocyte populations and trigger airway remodeling. To ob...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080867 | MassIVE
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