Sort   by:  
 Page size 
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
MetabolomicsHuman primary astrocytes finger- and footprinting metabolomics indicate biochemical alterations under ayahuasca treatment
Not available
ORGANISM(S): Homo sapiens 
ST002401 | MetabolomicsWorkbench
TranscriptomicsRapid reprogramming of primary human astrocytes into potent tumor initiating cells with defined genetic factors
Cancer stem cells play key roles in human malignancies. However, their cellular and molecular origins are still poorly understood. Here we report the successful generation of cancer stem cells from primary human astrocytes by use of defined genetic factors. Combined transduction of four factors —m...
ORGANISM(S): Homo sapiens 
2016-11-07 | E-MTAB-4771 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fetal primary astrocytes treated with the insectisides Cyfluthrin and Chlorpyrifos
Given the widespread use of insecticides in the environment, it is important to perform studies evaluating their potential effects on humans. Organophosphate insecticides, such as chlorpyrifos, are being phased out; however, the use of pyrethroids in household pest control is increasing. While chlor...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-5023 | biostudies-arrayexpress
ProteomicsProfiling the proteomic inflammatory state of human astrocytes using DIA mass spectrometry
In the present study we used DIA MS to characterize the profile of over 4,000 proteins in immortalized human astrocytes exposed to TNF, IL-1β, and LPS, as well as in primary human astrocytes cocultured with brain endothelial cells and exposed to LPS. For both immortalized and primary astrocytes, DIA...
ORGANISM(S): Homo sapiens (Human) 
2018-12-10 | PXD009891 | Pride
Dia ms human astrocytes inflammation 
TranscriptomicsTranscription profiling of human astrocytes grown in normoxia vs. hypoxia
Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular level, including the alteration of gene expression. Astrocytes play critical roles in the proper function...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3045 | biostudies-arrayexpress
TranscriptomicsDIRECT CONVERSION OF FIBROBLASTS INTO FUNCTIONAL ASTROCYTES BY DEFINED TRANSCRIPTION FACTORS
Direct cell reprogramming has enabled the direct conversion of skin fibroblasts into functional neurons and oligodendrocytes using a minimal set of cell lineage-specific transcription factors. This approach has substantial advantages since it is rapid and simple, generating the cell type of interest...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59018 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of HeLa cell line and primary human astrocytes under normoxic and hypoxic conditions to identify hypoxia-responsive genes in primary human astrocytes
Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular levels, including the alteration of gene expression. Astrocytes play critical roles in the proper functioni...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4483 | biostudies-arrayexpress
TranscriptomicsToward a Better Understanding of Potential Roles of Astrocytes in HIV-1-associated Neurocognitive Disorders
We present a microarray analysis of primary mouse astrocytes exposed to HIV-1 in culture. Results are compared with previous genomic studies of HIV-1 effect in human astrocytes and human and macaque brains. Day-two neonatal mouse astrocytes were exposed in triplicates to cell-free HIV-1/NL4-3 at m.o...
ORGANISM(S): Mus musculus 
2009-08-05 | E-GEOD-17383 | biostudies-arrayexpress
Sort   by:  
 Page size