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MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsInhibiting glutaminase exerts opposite effects on ovariectomy-induced and age-related reductions in murine bone mass
Recent studies have provided links between glutamine metabolism and bone remodeling, but little is known about its role in primary osteoporosis progression. We aimed to determine the effects of inhibiting glutaminase (GLS) on two types of primary osteoporosis and elucidate the related metabolism. To...
2024-06-17 | MTBLS9415 | MetaboLights
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
ProteomicsComprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from multiple tissues but require invasive harvesting and imply donor-to-donor variability. Embryonic stem cell-derived MS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080827 | MassIVE
ProteomicsMulti-omics approach to identify age-related changes in mesenchymal stem cells
Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-22 | MSV000079981 | MassIVE
TranscriptomicsA calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration. The latter makes use of calcium phosphate-based bone void fillers to heal bone defects, but it is currently not known how Ca2+ released from these c...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7222 | biostudies-arrayexpress
TranscriptomicsIdentity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow (I)
Human bone marrow mesenchymal stem cells (hBM-MSCs) hold promise for treating diseases for which currently no therapeutic options exist. High quantities of MSCs are needed, requiring extensive cell expansion in long-term culture. However, the fundamental biological properties of MSCs can be altered ...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-68926 | biostudies-arrayexpress
TranscriptomicsGene expression profiling on FePro labeled bone marrow stromal cells
Superparamagnetic iron oxide nanoparticles (SPION) are increasingly used to label human bone marrow stromal cells (BMSCs, also called mesenchymal stem cells) to monitor their fate by in vivo MRI and histology after Prussian blue (PB) staining. SPION-labeling appears to be safe as assessed by in vitr...
ORGANISM(S): Homo sapiens 
2011-01-24 | E-GEOD-20431 | biostudies-arrayexpress
TranscriptomicsAssociation between in vivo bone formation and ex vivo migration capacity of human bone marrow stromal cells
Introduction: There is a clinical need for developing systemic transplantation protocols for use of human skeletal stem cells (also known bone marrow stromal stem cells) (hBMSC) in tissue regeneration. In systemic transplantation studies, only a limited number of hBMSC home to injured tissues sugges...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-69358 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mesenchymal stem cells exposed to CM from tumor cells or bone marrow
Gene Expression profile of MSCs exposed to CM from tumor cells or bone marrow.
ORGANISM(S): Rattus norvegicus 
2006-05-30 | E-MEXP-532 | biostudies-arrayexpress
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