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ProteomicsCharacterization of detergent insoluble proteome in chronic traumatic encephalopathy
Proteomic sequencing of postmortem human brain can identify dysfunctional proteins that contribute to neurodegenerative disorders like Alzheimer’s disease and frontotemporal dementia. Similar studies in chronic traumatic encephalopathy are limited, but may provide important new insights into this di...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD007694 | Pride
Proteostasis Ad Detergent insoluble proteome Human brain cte Alzheimer's disease Dementia pugilistica 
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
ProteomicsA proteomic network approach resolves stage-specific molecular phenotypes in chronic traumatic encephalopathy
There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau. The underlying molecular events that cause these abnormal protein accumulations remain unclear. Here, we hypot...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024724 | Pride
Wgcna Tmt Cte 
UnknownCortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE.
Not available
S-EPMC11348287 | biostudies-literature
GenomicsTranscriptome analysis of CTE, CTE/AD and AD
Transcriptome network analysis of chronic traumatic encephalopathy and Alzheimer’s disease show altered expression of synaptotagmins associated with long-term potentiation
PRJEB28518 | ENA
TranscriptomicsTranscription profiling of human glial brain tumors
Gene expression profiling in 50 glial brain tumors and 4 normal brains using 42,000-feature cDNA microarrays (from total RNA). Tumors: 50 fresh-frozen glioma specimens subjected to standard WHO classification. Specimens included astrocytic [2 juvenile pilocytic astrocytomas, 1 low-grade astrocytic g...
ORGANISM(S): Homo sapiens 
2005-10-06 | E-SMDB-3152 | biostudies-arrayexpress
TranscriptomicsADAR2 reproducibly changes abundance and sequence of mature microRNAs in the mouse brain [gene expression]
Background: Adenosine deaminases that act on RNA (ADARs) bind to double-stranded and structured RNAs and deaminate adenosines to inosines. This A to I editing is widespread and required for normal life and development. Besides mRNAs and repetitive elements, ADARs can target miRNA precursors. Editing...
ORGANISM(S): Mus musculus 
2014-10-02 | E-GEOD-61067 | biostudies-arrayexpress
UnknownEvolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy.
Not available
S-EPMC7484331 | biostudies-literature
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