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ProteomicsStable isotope dynamic labelling of secretomes C4PR_LIV
We improve on currently-available resources by describing a mass spectrometry (MS)-based strategy using stable isotope dynamic labelling of secretomes (SIDLS) that discriminates between authentic secretory proteins and intracellular proteins within the secretome of cultured cells. By monitoring the ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-08 | PXD007231 | Pride
Human cancer cells secretome dynamic labelling 
ProteomicsStable isotope dynamic labelling of secretomes: Strataclean Linearity C4PR_LIV
We improve on currently-available resources by describing a mass spectrometry (MS)-based strategy using stable isotope dynamic labelling of secretomes (SIDLS) that discriminates between authentic secretory proteins and intracellular proteins within the secretome of cultured cells. By monitoring the ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-08 | PXD009838 | Pride
Human Secretome Oesophageal cancer 
ProteomicsSecretome of cancer-associated fibroblasts (CAFs) influences drug sensitivity in cancer cells
Resistance is a major problem with effective cancer treatment and the stroma forms a significant portion of the tumor mass but traditional drug screens involve cancer cells alone. Cancer-associated fibroblasts (CAFs) are a major tumor stroma component and its secreted proteins may influence the func...
ORGANISM(S): Homo sapiens (Human) 
2024-05-29 | PXD048307 | Pride
Cancer-associated fibroblasts Caf Secretome 
TranscriptomicsSenescence secreted factors activate Myc and sensitize pre-transformed cells to TRAIL-induced apoptosis
Senescent cells secrete a plethora of factors with potent paracrine signaling capacity. Strikingly, senescence, which acts as a defense against cell transformation, exerts pro-tumorigenic activities through its secretome by promoting numerous tumor-specific features, such as cellular proliferation, ...
ORGANISM(S): Homo sapiens 
2014-01-15 | E-GEOD-49944 | biostudies-arrayexpress
ProteomicsExosomal markers in secretome of Kamepferitrin-treated HepG2 cells
Kaempferitrin is extracted in significantly high quantities from the leaves of Cinnamomum osmophloeum, which belongs to the genus Cinnamomum, the same genus many antidiabetic herbal remedy in Chinese medicine. Oral administration of kaempferitrin reduces blood sugar in alloxan-induced diabetic rats....
ORGANISM(S): Homo sapiens (Human) 
2021-02-01 | PXD022181 | Pride
Human Kamepferitrin Secretome 
ProteomicsRepurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus
To combat methicillin-resistant Staphylococcus aureus (MRSA) infections novel drugs are desperately needed. From a screen, we found that the anti-cancer drug sorafenib effectively kills MRSA strains. By synthetic variation of key structural features, we identified a potent analog, PK150, exhibiting ...
ORGANISM(S): Staphylococcus aureus 
2019-09-09 | PXD012946 | Pride
Full proteome Affinity-based protein profiling (afbpp) Q exactive plus Chemical proteomics Staphylococcus aureus subsp. aureus nctc 8325 Secretome Surfaceome Orbitrap fusion 
ProteomicsNOTCH1 mediates a reciprocal switch between two distinct secretomes during senescence
Senescence, a persistent form of cell cycle arrest, is often associated with a diverse secretome, which provides complex downstream functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence (OIS) is accompanied by a dynamic fluctuation of NOTCH1 a...
ORGANISM(S): Homo sapiens (Human) 
2016-08-03 | PXD004168 | Pride
Plasma membrane profiling Senescence Notch Ras Silac 
Transcriptomicsmyocardial infarction in Reg3beta knock-out mice
Affymetrix microarray analysis of molecular changes after myocardial infarction. Samples of heart tissue were analyzed after myocardial infarction from WT and reg3beta knock-out mice. Samples from scar tissue and samples adjacent to the scar were analyzed. In the experiment we primarily compared inf...
ORGANISM(S): Mus musculus 
2015-06-29 | E-MTAB-2561 | biostudies-arrayexpress
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