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ProteomicsPrimary human cardiac ventricular fibroblasts
Transformed AC16 cells were acquired from Millipore and used at P10-15 and expanded in DMEM/F-12 with 10% FBS (Gibco). Primary human ventricular cardiac fibroblasts were acquired from Promocell and expanded in FGM-3 (Promocell) and used at P3-5. For the experiment, cells were separately placed on tr...
ORGANISM(S): Homo Sapiens (human) 
2023-05-05 | PXD041982 | JPOST Repository
ProteomicsTranscriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis
Activated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence of CF in active state inflicts deleterious heart function effects....
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD034244 | Pride
Cardiac fibroblasts  cardiac fibrosis  myofibroblasts  transcriptomics  quantitative proteomics 
ProteomicsCardiomyocytes regulate cardiac fibroblast activation and oxidative stress via CK2 signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGFβ induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, with dy...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD038854 | Pride
Cardiac fibroblasts Cardiomyocytes Proteomics Ck2 Signaling 
ProteomicsDistinct phenotypes induced by acute hypoxia and TGF-β1 in human adult cardiac fibroblasts
Myocardial infarctions cause hypoxic injury to downstream tissue and a consequent fibrotic remodeling process to replace injured tissue with a scar. Scar formation occurs through phases of wound healing in which stimuli such as transforming growth factor-beta (TGF-β) drive cardiac fibroblasts to act...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD051197 | Pride
Hypoxia Transforming growth factor-beta Cardiac fibrosis Hypoxia-inducible factors Myocardial infarction 
TranscriptomicsReversible and irreversible differentiation of cardiac fibroblasts
Aim: Differentiation of cardiac fibroblasts (Fb) into myofibroblasts (MyoFb) is responsible for connective tissue buildup in myocardial remodeling. We examined reversibility of MyoFb differentiation. Methods and Results: Adult rat cardiac Fb were cultured on a plastic substratum providing mechanical...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-51824 | biostudies-arrayexpress
TranscriptomicsProtective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling
1.1 Introduction Cardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is m...
ORGANISM(S): Homo sapiens 
2024-11-30 | E-MTAB-14602 | biostudies-arrayexpress
GenomicsGene expression data from normal human atrial cardiac fibroblasts, normal human ventricular cardiac fibroblasts, normal human dermal fibroblasts, human bone marrow-derived mesenchymal stem cells and human iPS cell-derived fibroblasts.
Gene expression data from normal human atrial cardiac fibroblasts, normal human ventricular cardiac fibroblasts, normal human dermal fibroblasts, human bone marrow-derived mesenchymal stem cells and human iPS cell-derived fibroblasts.
PRJNA837975 | ENA
GenomicsHuman Cardiac Fibroblasts in Producing Cell-Derived Matrices
Human Cardiac Fibroblasts in Producing Cell-Derived Matrices
PRJNA648986 | ENA
TranscriptomicsGene expression profile of human cardiac fibroblasts (HCFs), induced cardiomyocytes (iCMs), and heart
Global gene expression profile of total 24460 probes in the iCMs. The gene expression shifts from a fibroblast state toward a cardiac-like phenotype by Gata4/Mef2c/Tbx5/Mesp1/Myocd (GMTMM) or GMTMM/miR-133 transduction at 7 days after transduction. MiR-133 silenced fibroblast signatures in parallel ...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-56874 | biostudies-arrayexpress
ProteomicsHuman cardiac fibroblast membrane proteome
Cardiac Fibroblasts (CFs) are one of the main cell populations in the heart and play important roles in tissue homeostasis and in myocardial fibrosis. The study of these cells has been hampered by the lack of reliable membrane markers: none of the antigens currently used for characterization and iso...
ORGANISM(S): Homo sapiens (Human) 
2018-05-11 | PXD007839 | Pride
Human cardiac fibroblasts Myocardium Membrane proteins 
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