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MetabolomicsGut Microbiota-Derived Riboflavin Mediates Protective Effects of MUC2 in Acute Pancreatitis via CD40-Macrophage Pathway

Gut barrier dysfunction is critical in the pathogenesis of acute pancreatitis (AP), yet the underlying mechanisms remain unclear. Mucin 2 (MUC2), the primary component of the intestinal mucus layer, is essential for gut homeostasis and microbial eubiosis. This study aimed to elucidate the protect...

2025-09-05 | MTBLS12943 | MetaboLights
TranscriptomicsGenetically-driven target tissue over-expression of CD40: A novel mechanism in autoimmune disease
The CD40 gene, an important immune regulatory gene, is also expressed and functional on non-myeloid derived cells, many of which are targets for tissue specific autoimmune diseases, including d thyroid follicular cells in Graves’ disease (GD). Whether target tissue CD40 expression plays a role in au...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-39081 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Burkitts lymphoma cells (L3055) treated with low and high concentrations of CD154
Activated B cells reacting to small amounts of CD40 ligand (CD154) maintain homeostasis by suppressing default apoptosis. Additional outcomes, particularly differentiation, demand higher CD40 occupancy. Here we compared changes in the transcriptome of pleiotropically competent, early-passage L3055 B...
ORGANISM(S): Homo sapiens 
2007-05-31 | E-MEXP-1113 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HUVEC T-cell (CD40L+) induced, anti-CD40-siRNA treated
The CD40-CD40L dyad seems to play a prominent role fostering the immune-inflammatory response triggered by endothelial cell (EC)-T cell interaction. To comprehensively delineate the involvement of CD40 (TNFRSF5) in EC activation, we combined RNAi-mediated CD40 knock-down with comparative genome-wide...
ORGANISM(S): Homo sapiens 
2009-02-21 | E-GEOD-10601 | biostudies-arrayexpress
ProteomicsAnalysis of CD40 interactome in primary B cells
CD40 (also known as TNFRSF5) is a critical transmembrane molecule expressed on B cells and on myeloid cells including DCs. In B cells, CD40 engagement by its ligand CD40L (CD154) is essential to promote immunoglobulin class switching, memory differentiation, and germinal center formation. Using affi...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD042695 | Pride
Tnfrsf5 Ap-ms Human cd40 Mouse b cells Interactome Ost tag 
TranscriptomicsCD40-activation of human B cells
Antibody-independent effector functions of B cells, such as antigen presentation and cytokine production, have been shown to play an important role in a variety of immune-mediated conditions such as autoimmune diseases, transplant rejection and graft-versus-host disease. Therapeutic strategies, whi...
ORGANISM(S): Homo sapiens 
2014-01-14 | E-GEOD-54017 | biostudies-arrayexpress
TranscriptomicsGene expression of murine B cells activated via TLR4 or TLR4 + CD40: Group1 naM-CM-/ve B cells, Group2 LPS activated B cells 24h, Group3 LPS + anti-CD40 activated B cells 24h, Group4 LPS activated B cells 72h, and Group5 LPS + anti-CD40 activated B cells 72h.
Murine B cells can be activated via the surface receptors TLR4 and CD40. For a global assessment of differences in gene expression between these two different modes of B cell activation a genome wide transcriptome analysis was performed. In order to dissect different gene expression profiles of B ce...
ORGANISM(S): Mus musculus 
2014-02-24 | E-GEOD-35998 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in primary human leukaemic B-cells from peripheral blood and after culture on stromal cells in the presence and absence of CD154 and IL-4
Dynamic miRNA expression data in 377 miRNA present on Taqman low density array (TLDA) Human MicroRNA Array (A) plates (Applied Biosystems, #4398965). Primary human leukaemic B-cells were cultured for 24 hours on a stromal cell layer or a stromal cell layer with CD154 and IL-4 in order to find out ho...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-24694 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human immature monocyte-derived dendritic cells activated with anti-CD40 antibodies for 8 hours in the absence or presence of VAF347
VAF347 is a low molecular weight compound which inhibits allergic lung inflammation in vivo. This effect is likely due to a block of dendritic cell (DC) function to generate pro-inflammatory T-helper (Th) cells since VAF347 inhibits IL-6, CD86 and HLA-DR expression by human monocyte derived DC, thre...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-10463 | biostudies-arrayexpress
TranscriptomicsCD40-mediated amplification of local immunity by keratinocytes in impaired by HPV
The interaction between the transmembrane glycoprotein surface receptor CD40 expressed by skin keratinocytes (KCs) and its T cell-expressed ligand CD154 was suggested to exacerbate inflammatory skin diseases. However, the full spectrum of CD40-mediated effects by KCs underlying this observation is u...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-54181 | biostudies-arrayexpress
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