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MetabolomicsN-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression
Various cancers such as colorectal cancer (CRC) are associated with alterations in protein glycosylation. CRC cell lines are frequently used to study these (glyco)biological changes and their mechanisms. However, differences between CRC cell lines with regard to their glycosylation have hitherto bee...
2017-02-03 | MTBLS227 | MetaboLights
TranscriptomicsAll exon array expression data in normal colon and primary colon cancer lines [expression]
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, despite the fact that distal regulatory elements play a central role in controlling transcription patterns. Here we utilize the histone mark H3K4me1 to analyze gain and loss of en...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36400 | biostudies-arrayexpress
TranscriptomicsColon tumor samples
In response to polarization cues, cultured Caco-2 cells, a human colon adenocarcinoma-derived cell line, form a polarized epithelium resembling normal enterocytes. We investigated potential signaling mechanisms activated by Caco-2 cells that might trigger the genome-wide transcriptional reprogrammi...
ORGANISM(S): Homo sapiens 
2007-08-17 | E-GEOD-7466 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colon cancer cell line - ligand independent control
Control experiment to confirm ligand independent effect on gene regulation by ERb in HT29 cells. The colon cancer cell lines do not express endogenous ER but is made ERb-expressing by lentiviral transduction of an ERb expression cassette. Introduction of ERb makes it possible to study the role and f...
ORGANISM(S): Homo sapiens 
2011-05-29 | E-MEXP-3176 | biostudies-arrayexpress
ProteomicsTumor selective proteotoxicity of verteporfin inhibits colon cancer progression independent of YAP1
Verteporfin (VP) inhibts colon cancer growth in vivo and in cell lines by inducing high molecular weight oligomerization of proteins. The antitumor effect of VP is independent of its YAP inhibitor activity. Tumor hypoxia contributes partly to antitumor effect of VP by impairing clearance of VP-induc...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002793 | Pride
Human colon derived cancer cell lines 
TranscriptomicsRNA-seq of LGR5(+) and LGR5(-) cells isolated from human colon adenoma organoids and targeted DNA-seq of a colorectal biobank
This study has two components: (1) Human colon adenoma organoids (n=4 patients) were dissociated into single cells. Cells were incubated with a magnetic bead bound to an LGR5 antibody and run through a magnetic column. Magnet bound cells and flow through negative (FTN) cells were obtained. Magnet bo...
ORGANISM(S): Homo sapiens 
2020-04-30 | E-MTAB-4698 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of two human colon cancer cell lines derived from a primry tumor and a lypmh node metastatsis from a single patient reveals global alterations in mRNA polysomal recruitment in a cell model of colorectal cancer progression to metastasis.
Two colon cancer cell lines are under study. SW480 and SW620. The first one is derived from primary cancer, SW620 are from lymphnode metastatic sites. they both come from the sample patient. Polysomal RNA fractions from the two isogenic colon cancer cells lines was purified by sucrose gradient and h...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2509 | biostudies-arrayexpress
ProteomicsCharacterisation of cancer stem cells and the renin-angiotensin system in colon adenocarcinoma
LC-MS/MS Proteomics was performed to determine proteomic differences between colon adenocarcinoma (CA) tissues and patient-matched normal colon tissues, CA-derived primary cell lines and NC-derived primary cells, and between LGCA tissues and cell lines and HGCA tissues and cell lines. Biological pro...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD024449 | Pride
Crc Primary cell lines Colon adenocarcinoma Lc-ms/ms 
TranscriptomicsTranscription profiling of human colon cancer cell lines
Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERb-mediated gene regulation in the two colon cancer cell lines HCT116 and HT29. The colon cancer cell lines do not express endogenous ER but is made ERb-expressing by lentiviral transduction of an ...
ORGANISM(S): Homo sapiens 
2011-04-15 | E-MEXP-3169 | biostudies-arrayexpress
TranscriptomicscaArray_notte-00422: Molecular Dissection of Colon Cancer
RNA expression data was generated as part of a colon cancer study. Samples were obtained from patients, including primary colon cancer, polyps, metastases, and matched normal mucosa (obtained from the margins of the resection). The RNA was extracted from tissue samples obtained from resections and h...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-68468 | biostudies-arrayexpress
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