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MetabolomicsAndrogens drive SLC1A5-dependent metabolic reprogramming in polycystic ovary syndrome-GC-MS analysis of follicular fluid
Polycystic ovary syndrome (PCOS) is the primary cause of female infertility. Growing evidence suggests that dysregulation of amino acid metabolism plays a significant role in the onset and progression of PCOS. However, the underlying mechanism remains unclear. In this study, we conducted targeted me...
2025-04-14 | MTBLS12371 | MetaboLights
MetabolomicsResolvin E1 in follicular fluid acts as a potential biomarker and improves oocyte developmental competence by optimizing cumulus cells

The metabolic profile of follicular fluid (FF) has been investigated to look for biomarkers for oocyte quality. Resolvin E1 (RvE1), a potent pro-resolving mediator, was reported to have protective action in cell function. The study aimed to examine the predictive value of RvE1 for oocyte quality ...

2020-03-26 | MTBLS1488 | MetaboLights
MetabolomicsUHPLC-OE-MS metabolic profile of follicular fluid in patients with ovarian endometriosis: a pilot study of an endometriosis cohort

BACKGROUND: Endometriosis is a common benign gynaecological disorder. A number of studies have confirmed that the occurrence of disease in endometriosis patients is associated with metabolic changes in biological fluids and tissues. We set out to investigate the metabolic charact...

2024-02-20 | MTBLS8621 | MetaboLights
ProteomicsHuman follicular fluid hormone metabolism HPLC-MSMS
The concentrations of twenty kinds of hormones in the follicular fluid were detected by high-performance liquid chromatography–mass spectrometry (HPLC-MS/MS). An Agilent 1200 series high-performance liquid chromatography (HPLC) instrument (Agilent, USA) was utilized. A PAL autosampler (CTC, Swiss) a...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031559 | Pride
Human Hplc-msms Follicular fluid 
ProteomicsHuman follicular fluid neurotransmitters LC-MSMS
Pretreated human follicular fluid was prepared for targeted metabolomics experiments. For this purpose, 12-point standard calibration curves in the respective range with reference material were measured, and the limit of detection (LOD) and limit of quantification (LOQ) for each neurotransmitter und...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031560 | Pride
Human Lc-msms Follicular fluid 
Proteomicshuman follicular fluid lc-ms/ms
This study aimed to reveal if peptide profiling of individual human follicular fluid could become a new non-invasive predictive biomarker for oocyte quality, and attempted to discover candidate biomarkers for fertilization. In biomarker studies, because of normal clinical or biological variabil-ity,...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD003340 | Pride
Follicular fluid Human Lc-ms/ms 
ProteomicsProtein profile of follicular fluid from the heat-stressed cow
Direct exposure to physiologically-relevant elevated temperatures during the first half of in vitro maturation heightens cumulus-derived progesterone production, suppresses matrix metallopeptidase 9 secretion, and alters cumulus transcriptome. We hypothesized that heat-induced perturbations in cumu...
ORGANISM(S): Bos taurus (Bovine) 
2020-01-13 | PXD015735 | Pride
Follicular fluid Tmt Heat stress Bovine Lc-msms 
TranscriptomicsmiRNAs in follicular fluid
Our aim with this work is to identify and quantify the miRNA profile of the human follicular fluid using a miRNA microarray approach in young and advanced-aged women and in follicles with different oocyte quality. Data collected in this study would be utilized in a future as a marker to predict the...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-63737 | biostudies-arrayexpress
ProteomicsProteome and peptidome of human follicular fluid
Human follicular fluid (hFF) is a natural environment of oocyte maturation, and some components of hFF could be used to judge oocyte capability for fertilization and further development. In our pilot small scale study three samples from four donors (12 samples in total) were analyzed to determine wh...
ORGANISM(S): Homo sapiens (Human) 
2017-07-04 | PXD006550 | Pride
Human Follicular fluid Swath Lc-ms/ms 
ProteomicsProteomic analysis of follicular fluid of Patients with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common disorder encompassing reproductive, metabolic, and endocrine abnormalities, affecting 5 to 10% of women of reproductive age.To reveal the differences in proteomic profiles of follicular fluid between patients with and without PCOS and explore possible mec...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031996 | Pride
Proteomics Follicular fluid Tandem mass tag Polycystic ovary syndrome 
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