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MetabolomicsMetabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess
Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks re...
2015-04-09 | MTBLS103 | MetaboLights
TranscriptomicsExpression data from human coronary artery endothelial cells treated with HDL components
We quantified differential gene (mRNA) expression in human coronary artery cells treated with native HDL, reconstituted HDL, lipid-free apolipoprotein A-I, small unilamellar vesicles, or PBS control. These data were used to determine which genes are regulated by native HDL compared to components of ...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-53201 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from human coronary artery endothelial cells treated with HDL components
We quantified differential microRNA (miRNA) expression in human coronary artery cells treated with native HDL, reconstituted HDL, lipid-free apolipoprotein A-I, small unilamellar vesicles, or PBS control. These data were used to determine whichmiRNAs are regulated by native HDL compared to component...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-53315 | biostudies-arrayexpress
TranscriptomicsEffect of fetal HDL on gene expression in human placental endothelial cells
The aim of this study was to identify HDL and apoE-regulated genes in human placental endothelial cells (HPEC), which are exposed to fetal HDL. HPECs extracted from 5 human placentas were cultivated and treated for 16 h with 15ug/ml fetal HDL, 15ug/ml reconstituted HDL (rHDL), or endothelial basal m...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-MEXP-3299 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression data from human high-density lipoproteins.
We quantified differential microRNA (miRNA) expression on human HDL before and after incubation with human coronary artery endothelial cells. These data were used to determine which miRNAs are altered on HDL (taken up or effluxed to) by human coronary artery endothelial cells. Each group had a n=4 a...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-53314 | biostudies-arrayexpress
ProteomicsHuman HDL 2D-LC-MS/MS
Besides modulation of reverse cholesterol transport, high density lipoprotein (HDL) is able to modulate vascular function by stimulating endothelial nitric oxide synthase. Recently, it could be documented that this function of HDL was significantly impaired in patients with chronic heart failure (CH...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080857 | MassIVE
ProteomicsHDL proteome across 93 mouse strains
High-density lipoproteins (HDL) are nanoparticles with >80 associated proteins, phospholipids, cholesterol and cholesteryl esters. We have identified and quantified the ultracentrifugation isolated HDL proteome across 93 strains of mice, a diverse inbred strains of mice, Hybrid Mouse Diversity Panel...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-24 | PXD009473 | Pride
Hdl Strains Mouse 
TranscriptomicsIn vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei
The host range of African trypanosomes is influenced by innate protective molecules in the blood of primates. A subfraction of human high-density lipoprotein (HDL) containing apolipoprotein A-I, apolipoprotein L-I, and haptoglobin-related protein is toxic to Trypanosoma brucei brucei but not the hum...
ORGANISM(S): Trypanosoma brucei brucei 
2007-07-04 | E-GEOD-8369 | biostudies-arrayexpress
ProteomicsHuman HDL 2D-LC-MS/MS - Proteome profiles of HDL particles of patients with chronic heart failure are associated with immune response and also include bacteria proteins
Besides modulation of reverse cholesterol transport, high density lipoprotein (HDL) is able to modulate vascular function by stimulating endothelial nitric oxide synthase. Recently, it could be documented that this function of HDL was significantly impaired in patients with chronic heart failure (CH...
ORGANISM(S): Homo sapiens (Human) 
2016-01-04 | PXD002977 | Pride
Hdl variability  hdl functionality lc-ms/ms Human hdl 
TranscriptomicsMicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins (HG-U133 2.0)
Circulating microRNAs (miRNA) are relatively stable in plasma and are a new class of disease biomarkers. Here we present evidence that human high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities. Highly-purified fracti...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-25311 | biostudies-arrayexpress
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