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MetabolomicsDiagnostic Potential of Plasma IgG N-glycans in Discriminating Thyroid Cancer from Benign Thyroid Nodules and Healthy Controls

BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potent...

2021-09-01 | MTBLS2935 | MetaboLights
ProteomicsHuman IgG subclasses differ in structural elements of their N-glycosylation
We tested tryptic plasma samples using HILIC-LC-MS/MS, which included mixed human plasma as well as plasma from two healthy individuals collected at three different time points, approximately one month apart. Our focus was on the glycan structure of the Fc domain of IGG subclasses. The results indic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-13 | MSV000095017 | MassIVE
ProteomicsAutoantibodies are abundant in all human sera: a demographic characterization via protein microarrays
Human serum samples were probed onto human protein microarrays in order to ascertain the number and diversity of naturally ocurring self-reactive IgG autoantibodies. In the study presented here, 166 human serum samples were probed onto human protein microarrays in order to identify self-reactive IgG...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-39087 | biostudies-arrayexpress
TranscriptomicsHigh titers and low fucosylation of early anti-SARS-CoV-2 IgG promote hyper-inflammation by anti-inflammatory macrophages (MIL10)
Patients diagnosed with coronavirus disease 2019 (COVID-19) mostly become critically ill around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe acu...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-10431 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Podocytes reveal use of FcRn to clear IgG from the glomerular basement membrane
The glomerular filtration barrier prevents large serum proteins from being lost into the urine. It is not known, however, why the filter does not routinely clog with large proteins that enter the glomerular basement membrane (GBM). Here we provide evidence that an active transport mechanism exists t...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10017 | biostudies-arrayexpress
ProteomicsProfiling of Subclass-Specific IgG Glycosylation in Colorectal Cancer
Changes in IgG glycosylation have been reported to be associated with colorectal cancer (CRC), but the alteration in specific subclass of IgG is unknown. Herein, we optimized five common IgG glycopeptides enrichment methods to acquire comprehensive profiling of IgG glycoproteomics in CRC. Notably, i...
ORGANISM(S): Homo sapiens (Human) 
2022-10-27 | PXD016318 | Pride
Human Serum igg Complete tryptic digestion Colorectal Lc-ms/ms 
TranscriptomicsMiRNA-127 Inhibits IgG Immune Complex-induced Lung Inflammation by Targeting IgG Fcγ Receptor I
The molecular mechanisms of acute lung injury are incompletely understood. MicroRNAs (miRNAs) are crucial biological regulators that act by suppressing their target genes and are involved in a variety of pathophysiologic processes. MiR-127 appeared to be down-regulated during lung injury. We set out...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-27642 | biostudies-arrayexpress
ProteomicsMiddle-up analysis of polyclonal IgG-Fc
Middle-up strategy for the analysis of the fragment crystallizable (Fc) region of human plasma immunoglobulins G (IgGs). The use of hydrophilic interaction liquid chromatography (HILIC) and capillary electrophoresis (CE) coupled to mass spectrometry (MS) allowed to get a comprenhesive view of the N-...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-08 | MSV000085388 | MassIVE
TranscriptomicsLongitudinal clonal IgG cross-reactivity profiles of coronavirus-specific B-cells in COVID-19 patients
We investigated the kinetics, breadth, magnitude, and level of cross-reactivity of IgG antibodies against SARS-CoV-2 and heterologous seasonal (HCoV-NL63, -229E, -OC43 and -HKU1) and epidemic coronaviruses (SARS-CoV, hCoV-MERS) at the clonal level in patients with mild or severe COVID-19 as well as ...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12161 | biostudies-arrayexpress
ProteomicsChemical labeling for fine mapping of IgG N-glycosylation by ETD-MS
Immunoglobulin G (IgG), which contains four subclasses (IgG1-4), is one of the most important class of glycoproteins in immune system. Because of its importance in immune system, a steady increase of interest in developing IgG as biomarker or biotherapeutic agents for the treatment of diseases has b...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD014713 | Pride
Chemical labeling Igg Glycosylation Glycopeptides Electron transfer dissociation (etd) mass spectrometry 
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