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MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
TranscriptomicsmRNA array profiling on human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin
Cardiomyocytes derived from human pluripotent stem cells were exposed to the cardiotoxic drug Doxorubicin in order to assess the utility of this cell system as a model for drug-induced cardiotoxicity. Cells are exposed to different concentrations of doxorubicin for up to 48 hours followed by a 12 da...
ORGANISM(S): Homo sapiens 
2017-12-19 | E-MTAB-6045 | biostudies-arrayexpress
TranscriptomicsExpression profiling analysis of differentiating human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes
This SuperSeries is composed of the following subset Series: GSE35671: Comparison of mRNA expression profiling of differentiating human-induced pluripotent stem cell (hiPSC)–derived cardiomyocytes, biopsies from fetal, adult and hypertensive human hearts and primary cardiomyocytes GSE35672: miRNA ex...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35673 | biostudies-arrayexpress
ProteomicsLactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs
top down and bottom up proteomics files for Lactate and Immunomagnetic-purified iPSC-derived Cardiomyocytes Generate Comparable Engineered Cardiac Tissue Constructs
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-05-05 | MSV000091869 | MassIVE
TranscriptomicsmiRNA expression profiling of differentiating human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes
To gain insight into the molecular regulation of human heart development, a detailed comparison of the mRNA and miRNA transcriptomes across differentiating human-induced pluripotent stem cell (hiPSC)–derived cardiomyocytes and biopsies from fetal, adult, and hypertensive human hearts was performed. ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35672 | biostudies-arrayexpress
ProteomicsProlyl hydroxylation regulates protein degradation, synthesis and splicing in human induced pluripotent stem cell-derived cardiomyocytes
Protein hydroxylases are oxygen and alpha-ketoglutarate-dependent enzymes that catalyze hydroxylation of amino acids such as proline, thus linking oxygen and metabolism to enzymatic activity. Prolyl hydroxylation is a dynamic post-translational modification that regulates protein stability and prote...
ORGANISM(S): Homo sapiens (Human) 
2016-05-06 | PXD003621 | Pride
Lc-ms/ms Amino acid labeling Prolyl hydroxylation Ipsc-derived cardiomyocytes 
TranscriptomicsComparison of mRNA expression profiling of differentiating human-induced pluripotent stem cell (hiPSC)–derived cardiomyocytes, biopsies from fetal, adult and hypertensive human hearts and primary cardiomyocytes
To gain insight into the molecular regulation of human heart development, a detailed comparison of the mRNA and miRNA transcriptomes across differentiating human-induced pluripotent stem cell (hiPSC)–derived cardiomyocytes and biopsies from fetal, adult, and hypertensive human hearts was performed. ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35671 | biostudies-arrayexpress
TranscriptomicsMicroRNA array profiling on human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin
Cardiomyocytes derived from human pluripotent stem cells were exposed to the cardiotoxic drug Doxorubicin in order to assess the utility of this cell system as a model for drug-induced cardiotoxicity. Cells are exposed to different concentrations of doxorubicin for up to 48 hours followed by a 12 da...
ORGANISM(S): Homo sapiens 
2017-10-28 | E-MTAB-6052 | biostudies-arrayexpress
MetabolomicsMitochondrial Transplantation Ameliorates Doxorubicin-Induced Cardiac Dysfunction via Activating Glutamine Metabolism
Doxorubicin is a wildly used effective anticancer agent. However, doxorubicin use is also related to cardiotoxic side effect in some patients. Mitochondrial damage has been shown to be one of the pathogeneses of doxorubicin-induced myocardial injury. In this study, we test the hypothesis that mitoch...
2025-03-13 | MTBLS7989 | MetaboLights
TranscriptomicsComparative global transcriptomic profiling of human ES and iPSs cells and their derived microdissected cardiac clusters
Recent establishment of induced pluripotent stem (iPS) cells opened new avenues for generating human patient-specific stem cell derivatives that can be used for in vitro modeling of human disease, drug development and cell replacement therapy. In this study we analyzed the molecular and functional p...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-17579 | biostudies-arrayexpress
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