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MetabolomicsMethionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met-C gen...

2025-07-05 | MTBLS12457 | MetaboLights
MetabolomicsMass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

Human brain organoids are emerging models to study human brain development and pathology as they recapitulate the development and characteristics of major neural cell types, and enable manipulation through an in vitro system. Over the past decade, with the advent of spatial technologies,...

2023-05-23 | MTBLS7565 | MetaboLights
TranscriptomicsPathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1
Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neural degeneration. Here, we have combined reprogramming...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-54409 | biostudies-arrayexpress
TranscriptomicsEffects of human skeletal muscle fibroblast and stem cell media on cultured rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Rattus norvegicus 
2026-02-21 | E-MTAB-14399 | biostudies-arrayexpress
TranscriptomicsAccelerated high-yield generation of limb-innervating motor neurons from human stem cells
Human pluripotent stem cells are a promising source of diverse cells for developmental studies, cell transplantation, disease modeling, and drug testing. However, their widespread use even for intensely studied cell types like spinal motor neurons, is hindered by the long duration and low yields of...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-41795 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle fibroblasts and stem cells cultured with rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Homo sapiens 
2026-02-21 | E-MTAB-14395 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells
This experiment was conducted to identify the transcriptome of human GNRH1 cells which has never been reported before and this experiment has identified some novel molecules which might regulate GNRH1 neuron differentiation which could be further explored to identify the origin and development of...
ORGANISM(S): Homo sapiens 
2020-02-16 | E-MTAB-7938 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells (2)
This experiment was conducted to identify the transcriptome of human GNRH1 cells which has never been reported before and this experiment has identified some novel molecules which might regulate GNRH1 neuron differentiation which could be further explored to identify the origin and development of...
ORGANISM(S): Homo sapiens 
2020-02-16 | E-MTAB-7956 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle fibroblasts and stem cells cultured with rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Rattus norvegicus 
2026-02-21 | E-MTAB-14397 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of GNRH1 neurons differentiated from human pluripotent stem cells (1)
This experiment was conducted to identify the transcriptome of human GNRH1 cells which has never been reported before and this experiment has identified some novel molecules which might regulate GNRH1 neuron differentiation which could be further explored to identify the origin and development of...
ORGANISM(S): Homo sapiens 
2020-02-16 | E-MTAB-8519 | biostudies-arrayexpress
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