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MetabolomicsMetabolites of human neurons and stem cells (siNeuron metabolomics)
Not available
ORGANISM(S): Homo sapiens 
ST000768 | MetabolomicsWorkbench
MetabolomicsLysosome Lipid Signaling from the Periphery to Neurons Regulates Longevity

Lysosomes are key cellular organelles that metabolize extra- and intra-cellular substrates. Alterations in lysosomal metabolism are implicated in aging-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to ...

2022-05-06 | MTBLS4654 | MetaboLights
MetabolomicsMethionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

The folate and methionine cycles (Met-C) are regulated by vitamin B12 (B12), obtained exclusively from diet and microbiota. Met-C supports amino acid, nucleotide, and lipid biosynthesis and provides one-carbon moieties for methylation reactions. While B12 deficiency and polymorphisms in Met-C gen...

2025-07-05 | MTBLS12457 | MetaboLights
TranscriptomicsAccelerated high-yield generation of limb-innervating motor neurons from human stem cells
Human pluripotent stem cells are a promising source of diverse cells for developmental studies, cell transplantation, disease modeling, and drug testing. However, their widespread use even for intensely studied cell types like spinal motor neurons, is hindered by the long duration and low yields of...
ORGANISM(S): Homo sapiens 
2013-02-06 | E-GEOD-41795 | biostudies-arrayexpress
TranscriptomicsDeriving Dopaminergic Neurons for Clinical Use. A Practical Approach.
Identification of new small molecules that regulate the step-wise differentiation of hPSC into dopaminergic neurons population. Furthermore, the naturally occurring steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. Total RNA extracted...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-42265 | biostudies-arrayexpress
TranscriptomicsPathways Disrupted in Human ALS Motor Neurons Identified Through Genetic Correction of Mutant SOD1
Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neural degeneration. Here, we have combined reprogramming...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-54409 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of human fibroblasts and converted neurons
Human fibroblasts can be directly converted into cholinergic neurons by Neurogenin 2 (Neurog2 or NGN2) under the treatments of small molecules. Genome-wide analysis of gene expression was performed to examine the similarity of converted neurons to samples from human brain or spinal cord. Total RNA o...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-45954 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human and mouse stem-cell derived neurons and mouse primary cortical neurons after KCl-induced membrane depolarization against controls.
This experiment comprises RNA-seq data used to study evolutionary differences between humans and mice in neuronal activity-dependent transcriptional responses. Activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons were compared with those induced in deve...
ORGANISM(S): Mus musculus 
2017-02-16 | E-MTAB-5489 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle fibroblasts and stem cells cultured with rat motor neuron cells
The study was designed to compare whether and how muscle fibroblasts (FIB) and muscle stem cells (MYO) interact with motor neurons. Moreover, we aimed to investigate whether muscle cells, isolated from lifelong exercisers, exerted a protective and supportive effect on motor neurons. These object...
ORGANISM(S): Homo sapiens 
2026-02-21 | E-MTAB-14395 | biostudies-arrayexpress
GenomicsGene expression from human iPSC derived motor neurons.
Gene expression from human iPSC derived motor neurons.
EGAS00001003785 | EGA
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