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ProteomicsNormal human mitral valve proteome: a preliminary investigation by gel-based and gel-free proteomic approaches
The mitral valve is a highly complex structure which regulates blood flow from the left atrium to the left ventricle (LV) avoiding a significant forward gradient during diastole or regurgitation during systole. The integrity of the mitral valve is also essential for the maintenance of normal LV size...
ORGANISM(S): Homo sapiens (Human) 
2016-08-18 | PXD004397 | Pride
Human normal mitral valve Lc/mse Valvular interstitial cells 
TranscriptomicsExpression analysis of human aortic valve interstitial cells (hAVICs), mitral valve interstitial cells(hMVICs) and dermal firbroblasts (hDFs)
Investigation of whole genome gene expression level changes in hAVICs and hMVICs, compared to human dermal fibroblasts. A three chip assay using total RNA obtained from primary cultured normal valve interstital cells and human dermal fibroblasts was performed. Each chip measures the expression level...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-40801 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells
E12.5 AV cushion and E17.5 AV valve from wild-type FVB/N mice and in vitro cultured MC3T3 cells; In the study we demonstrated shared gene expression in embryonic heart valve development and Osteoblast progenitor cells. The atrioventricular (AV) valves of the heart develop from undifferentiated mesen...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11040 | biostudies-arrayexpress
TranscriptomicsAffymetrix GeneChip™ Canine Gene 1.1ST Array of canine heart valves in all stages of Myxomatous mitral valve disease (Normal-4)
Whole mitral valves from each Whitney grade of disease; normal (n=6), grade 1 (n=5), grade 2 (n=6), grade 3 (n=6) and grade 4 (n=5). mRNA was extracted using the qiagen RNeasy minikit and assessed by the agilent 2200 bioanalsyser. all samples passed quality control and transcriptomic analysis was pe...
ORGANISM(S): Canis lupus familiaris 
2019-12-26 | E-MTAB-8618 | biostudies-arrayexpress
ProteomicsIntegration of functional imaging, cytometry and unbiased proteomics reveals new features of endothelial-to-mesenchymal transition in ischemic mitral valve regurgitation in human patients
Background: Following myocardial infarction, mitral regurgitation (MR) is a common complication. Previous animal studies demonstrated the association of endothelial-to-mesenchymal transition (EndMT) with mitral valve (MV) remodeling. Nevertheless, little is known about how MV tissue responds to isch...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD025096 | Pride
Human Mitral valve (mv) Proteomic Ischemic mitral regurgitation (imr) Echocardiography Endothelial-to-mesenchymal transition (endmt) Histo-cytometry 
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
TranscriptomicsAffymetrix GeneChip™ Canine Gene 1.1ST Array of canine valves with myxomatous mitral valve disease with mild disease that are dissected into grossly diseased and grossly normal areas
A total of seven mildly diseased canine valves were dissected into grossly diseased and grossly normal areas of tissue (n=7 per group). mRNA was extracted using the qiagen RNeasy minikit and assessed by the agilent 2200 bioanalsyser. all samples passed quality control and transcriptomic analysis was...
ORGANISM(S): Canis lupus familiaris 
2019-12-26 | E-MTAB-8622 | biostudies-arrayexpress
Unknown3D Contractile and Remodeling Behaviors of Functionally Normal and Prolapsed Human Mitral Valve Interstitial Cells.
Not available
S-EPMC12633392 | biostudies-literature
ProteomicsProteomic analysis of pulmonary arteries and lung tissues from dogs affected with pulmonary hypertension secondary to degenerative mitral valve disease
In dogs with degenerative mitral valve disease (DMVD), pulmonary hypertension (PH) is a common complication characterized by abnormally elevated pulmonary arterial pressure (PAP). Pulmonary arterial remodeling is the histopathological changes of pulmonary artery that has been recognized in PH. The...
ORGANISM(S): Cellular Organisms 
2024-09-09 | PXD045240 | JPOST Repository
UnknownDecreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation.
Not available
S-EPMC9896655 | biostudies-literature
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