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TranscriptomicsGene expression profiles of canine and human osteosarcoma
This SuperSeries is composed of the following subset Series: GSE16087: Gene expression profiles of canine osteosarcoma GSE16088: Gene expression profiles of human osteosarcoma GSE16091: Gene expression profiles of human osteosarcoma, set2 Pulmonary metastasis continues to be the most common cause o...
ORGANISM(S): Homo sapiens 
2009-11-03 | E-GEOD-16102 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human osteosarcoma
Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatr...
ORGANISM(S): Homo sapiens 
2009-11-04 | E-GEOD-16088 | biostudies-arrayexpress
TranscriptomicsRNA Sequencing Quantitative Analysis of cell lines derived from tumours from two mouse models of human osteosarcoma that recapitulate clinically distinct human osteosarcoma subtypes.
Purpose: Osteosarcoma (OS) is the most common primary bone malignancy. OS consists of several subtypes including fibroblastic, osteoblastic and chondroblastic OS. We have developed genetically engineered mouse models of human OS that recapitulate two distinct subtypes, fibroblastic (Osx-CreLox p53-/...
ORGANISM(S): Mus musculus 
2015-07-06 | E-GEOD-58916 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human osteosarcoma Sa OS cells vs reference RNA of human osteosarcoma U-2 OS cells
Osteosarcoma (OS) is a common primary bone malignancy that is characterized by high degree of aneuploidy, gene amplification, and multiple unbalanced chromosomal rearrangements. The human osteosarcoma U-2 OS and Sa OS cells lines have been generated more than three decades ago and are used in a wide...
ORGANISM(S): Homo sapiens 
2009-09-21 | E-MEXP-1897 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of human osteosarcoma, set2
Pulmonary metastasis continues to be the most common cause of death in osteosarcoma. Indeed, the 5-year survival for newly diagnosed osteosarcoma patients has not significantly changed in over 20 years. Further understanding of the mechanisms of metastasis and resistance for this aggressive pediatr...
ORGANISM(S): Homo sapiens 
2009-11-04 | E-GEOD-16091 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [gene expression]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36001 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [DNA copy number]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36003 | biostudies-arrayexpress
TranscriptomicsGene expression of human paediatric osteosarcoma tumour samples relative to normal human osteoblasts
Gain or loss of genes and deregulation of gene expression can result in cumulative and progressive disruptions of normal cellular functions. Cancer-specific changes in gene expression play an essential role in cancer occurrence, and ultimately lead to cancer-related self-sufficiency in growth signal...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-12865 | biostudies-arrayexpress
TranscriptomicsIntegrative analysis reveals relationships of genetic and epigenetic alterations in osteosarcoma [methylation]
Osteosarcomas are the most common primary malignant tumours of bone, and almost all conventional osteosarcomas are high-grade tumours showing complex genomic aberrations. We have integrated genome-wide genetic and epigenetic profiles from the EuroBoNeT panel of 19 human osteosarcoma cell lines based...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-36002 | biostudies-arrayexpress
TranscriptomicsSyndecan-2 and apoptosis in osteosarcoma
Syndecan-2 was found to act as a tumor suppressor in osteosarcoma and to mediate the apoptotic response to cytotoxic agents. To determine new mechanisms that control cell survival and apoptosis in osteosarcoma cells, we aim to show target genes that are involved downstream of this proteoglycan durin...
ORGANISM(S): Homo sapiens 
2013-09-23 | E-GEOD-19913 | biostudies-arrayexpress
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