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MetabolomicsMulti-Omic Analysis and Platelet Function Distinguish Treatment Responses to Hydroxytyrosol in Cardiovascular Risk
Many polyphenols have been recognized for their antioxidant and health benefits. The present study attempted, for the first time, to determine the effects of daily oral intake of β-cyclodextrin-encapsulated hydroxytyrosol (HT) on plasma platelet reactivity and proteomic and metabolomic profiles of p...
2025-06-30 | MTBLS12336 | MetaboLights
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Platelet isolation and stimulation, targeted lipid mediator profiling

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1381 | MetaboLights
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Platelet isolation and stimulation, Targeted Phospho and Glycerolipid Profiling

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1369 | MetaboLights
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Platelet isolation and stimulation - DIA lipid mediator validation

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1382 | MetaboLights
MetabolomicsUntargeted Metabolomics of Mouse Platelet Pellets by LC-MS/MS
In this study, platelet pellets were isolated from mouse peripheral blood through gradient centrifugation to obtain high-purity platelet samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based untargeted metabolomics was performed to comprehensively profile the global metabolic chan...
2026-08-04 | MTBLS15244 | MetaboLights
TranscriptomicsMicro-Array Profiling Exhibits Remarkable Intra-Individual Stability of Human Platelet micro-RNA
Results: MiRNA expression profiling of 1281 human miRNAs revealed relevant expression of 221 miRNAs consistently expressed in all samples at all time points. Correlation of platelet miRNA ranks was highly significant with data from other studies. Global distribution of miRNA expression was relativel...
ORGANISM(S): Homo sapiens 
2012-06-19 | E-GEOD-33215 | biostudies-arrayexpress
ProteomicsHuman platelet detergent resistant membranes proteome
Here we characterized the proteins associated with detergent resistant membranes (DRMs) from resting and activated human platelets. We achieved a proteomic profile of 141 DRM proteins involved in many biological pathways including 'PAR-1-mediated thrombin signal events', 'Integrin family cell surfac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080708 | MassIVE
TranscriptomicsPlatelet microRNA-mRNA Co-Expression Profiles Correlate with Platelet Reactivity
MicroRNAs (miRNAs) regulate cell physiology by altering protein expression, but the biology of platelet miRNAs is largely unexplored. We tested whether platelet miRNA levels were associated with platelet reactivity by genome-wide profiling using platelet RNA from 19 healthy subjects. We found that...
ORGANISM(S): Homo sapiens 
2011-09-26 | E-GEOD-27917 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human platelet polyA-mRNA from a normal male
RNA-sequencing analysis of human platelet polyA-mRNA from a normal male. The goal of this experiment was to identify genes expressed in unstimulated circulating platelets.
ORGANISM(S): Homo sapiens 
2012-06-30 | E-MTAB-715 | biostudies-arrayexpress
MetabolomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
2025-12-05 | MTBLS9664 | MetaboLights
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