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ProteomicsSILAC pulse labeling in HGPS fibroblasts - HGPS samples
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006016 | Pride
Human progeria silac 
ProteomicsSILAC analysis of relative protein abundance in nuclei - AG3258 and AG11498
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006012 | Pride
Human progeria silac 
ProteomicsSILAC analysis of relative protein abundance in nuclei - PRF168 and PRF167
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006013 | Pride
Human progeria silac 
ProteomicsSILAC analysis of relative protein abundance in cytosol - AG3258 and AG11498
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006014 | Pride
Human progeria silac 
ProteomicsSILAC pulse labeling in HGPS fibroblasts - WT samples
Premature aging disorders provide a lens through which to study the drivers of aging. In Hutchinson-Gilford progeria syndrome (HGPS) a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We used stable isotope labeling and quantitative mass spectromet...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD006015 | Pride
Human progeria silac wild type controls 
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